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Imbalance in T-Helper 17 Cells and Targeted Therapy in an Infant with SAM-like Syndrome
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ÁNGEL BALLADARES
Imbalance in T-Helper 17 Cells and Targeted Therapy in an Infant with SAM-like Syndrome
DEFINITION
DEFINITION
SAM syndrome which is characterized by severe dermatitis, multiple allergies and metabolic wasting is a congenital skin disease caused by mutations in the genes encoding either desmoglein-1 or desmoplakin.
APPLICATIONS IN NURSING
Available treatments targeting th17 cells incluide biologic drugs that are currently licensed for psoriasis therapy. Such as ustekinumab and secukinumab. Ustekinumab was recently evaluated in two patients with DSP mutations but we had obtained littlecutaneous improvement in another patient with SAM syndrome who had DSG1 mutations.
PROS AND CONS
If traeted early, meconial aspiration syndrome has a positive prognosis and does not have to present further complications.
- Chemical aspiration pneumonia
- Brain damage due to lack of oxygen
- Shortness of breath lasting several days
- Pulmonary atelectasis
- Persistent pulmonary hypertension of the newborn
PROS AND CONS
ISSUE APPLIED TO ECUADOR
Between 9 and 15% of the participants are complicated by the presence of meconium in amniotic fluid and historically 5 to 12% of those cases developed SAM. This figure has dropped in developed countries to percentages between 1.6 to 3.9%.
ISSUE APPLIED TO ECUADOR
CONCLUSION
The major effect of secukinumab in ours patients quality of life supports interleukin-17A as a new target to treat patients with serious skin disorders
Treg would also join this group of cells that act both collaboratively and regulatoryly, since in addition to their known suppressive function they would also coordinate the first steps of viral infection directly as well as indirectly inducing, by secreting TGF- the diferrentiation of TH17.