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Cholera is a diarrheal illness caused by an intestinal infection with the Vibrio Cholerae bacteria. People can get this infection when they eat or drink an item with this bacteria in it. The symptoms of this illness can sometimes be mild or hvae none at all, but in other cases, it can be severe and life-threatening.
Tissue affected by Cholera
normal cell signaling pathways
Faulty cell signaling pathways
Symptoms can include:
Vomitting
Diarrhea
Dehydration
Mucle Cramps
Shock
Restlessness and Irritability
Scientists are developing improved vaccines for Cholera. And are currently devising new drugs based on molecules and natural products to treat Cholera.
Cholera toxin and other types of toxin produce a variety of extracellular prodeucts that have deleterious effects on eukaryotic cells.
Incorrect mechanism
The toxin cuases overactivation of signalling pathway that controls the activity of Cholride channel proteins.
"Illness and Symptoms | Cholera"CDC, https://www.cdc.gov/cholera/illness.html#:~:text=Cholera%20is%20an%20acute%20diarrheal,be%20severe%20and%20life%2Dthreatening. Accessed 15 Nov. 2022
"Cholera" World Health Organization, https://www.who.int/news-room/fact-sheets/detail/cholera Accessed 15 Nov. 2022
"Cholera - Symptoms and causes" Mayo Clinic, https://www.mayoclinic.org/diseases-conditions/cholera/symptoms-causes/syc-20355287?utm_source=Google&utm_medium=abstract&utm_content=Cholera&utm_campaign=Knowledge-panel Accessed 15 Nov. 2022