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Glycine

Chemical Structure

Chemical Structure

Chemical Formula

Chemical Formula

C H NO

2 5 2

  • Inhibitory Neurotransmitter in the CNS

  • Important for processing sensory and motor information that allows for movement, vision, and auditory functions

  • In some areas of the central nervous system, it is co-released with GABA

  • Stops N-methyl-D-aspartate (NMDA)

Functions

Glycine Encephalopathy

Medical Condition

Condition

  • Buildup of glycine in the body (mostly in the brain), due to lack of the enzyme that breaks down glycine

  • Most common in infants

  • Males are more likely to survive and have less developmental issues

  • Caused by mutated AMT gene or GLDC gene.
  • Lethargic

  • Feeding difficulties

  • Hypotonia (weak muscles)

  • Jerky movements

  • Breathing problems

  • Intellectual disabilities

  • Seizures

Symptoms

Glycine Reuptake Inhibitor:

Bitopertin

Medication

  • Glycine Transporter inhibitor

  • Increases levels of glycine by inhibiting its reuptake

  • Medication for Schizophrenia

  • Glycine Transporter inhibitor

  • Increases levels of glycine by inhibiting its reuptake

  • Medication for Schizophrenia

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