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Glycine Neurotransmitter
6
Transcript
Glycine
Chemical Structure
Chemical Structure
Chemical Formula
Chemical Formula
C H NO
2 5 2
- Inhibitory Neurotransmitter in the CNS
- Important for processing sensory and motor information that allows for movement, vision, and auditory functions
- In some areas of the central nervous system, it is co-released with GABA
- Stops N-methyl-D-aspartate (NMDA)
Functions
Glycine Encephalopathy
Medical Condition
Condition
- Buildup of glycine in the body (mostly in the brain), due to lack of the enzyme that breaks down glycine
- Most common in infants
- Males are more likely to survive and have less developmental issues
- Caused by mutated AMT gene or GLDC gene.
- Lethargic
- Feeding difficulties
- Hypotonia (weak muscles)
- Jerky movements
- Breathing problems
- Intellectual disabilities
- Seizures
Symptoms
Glycine Reuptake Inhibitor:
Bitopertin
Medication
- Glycine Transporter inhibitor
- Increases levels of glycine by inhibiting its reuptake
- Medication for Schizophrenia
- Glycine Transporter inhibitor
- Increases levels of glycine by inhibiting its reuptake
- Medication for Schizophrenia
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