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Eb la

viru

Ebola virus

Prepared by

Mahmoud Mohamed Yousef El-Baz

Al-Azhar University

Faculty of Agriculture

Biotechnology Department

(2020)

1976

(Democratic republic of congo)

Ebola river

Dr.peter piot

classification

Order: mononegavirales

(enveloped,nonsegment,negative strand RNA virous)

Family: floviridage

Genus:Ebola virus

Genus ebola virus comprised 5 distinct species :-

1.Bundibugyo ebola virus (BDBV)

2.Zaire ebola virus (EBOV)

3.Sudan ebola virus (SUDV)

4.Reston ebola virus (RESTV)

5.Tai forest ebola virus (TAFV)

Structure

  • Diameter 80 nm
  • lenght 960 nm to 1200 nm
  • RNA genome 19 kb long .
  • 7 structural and regulatory genes .

Transmission

fruit bates

(The natural host )

The fluids such as :

BLOOD

Blood

SWEAT

Sweat

TEARS

Tears

MUCUS

mucus

SALIVA

Saliva

VOMIT

Vomit

URINE

Urine

BREAST MILK

Breast milk

SEMEN

Semen

Symptoms

(incubation period)

Initial symptoms

High temperature

high temperature

rashes

Rashes

abdominal pain

Abdominal pain

nausea

Nausea

blood stream

Blood stream slow down

loss of appetite

loss of appetite

liver enzyme

Increased liver enzyme activity

Late symptoms

vomiting

vomiting

diarrhea

Diarrhea

pharyngitis

pharyngitis

prostration

prostration

vomiting blood

severe vomiting blood

hemorrhage

internal and external hemorrhages from orifices

low w.b.c

low white blood cell count

90% of patients die from the disease

Between 1976 and 2013 the world health organization report 24 outbreaks involving 2387 cases with 1590 deaths .

from December 2013 to January 2016 with 28646 cases and 11323 deaths .

TITLE

Diagnosis

  • Antibody capture (ELISA)

elisa

  • Antigen capture detection test

antigen capture

  • serum neutralization test

serum neutralization

RT-PCR

  • RT- PCR

ELECTRON MICROSCOPY

  • Electron microscopy
  • Virus isolation by cell culture

VIRUS ISOLATION

Treatment

List of Ebola virus drug

DRUGS

The best and most effective solution for treating symptoms :-

TITLE

Doctors manage the symptoms of Ebola with:

1.Fluids and electrolytes

2.maintaining Oxygen status and blood pressure.

3. Replacing lost blood .

4.Treatment for other infections.

Referances

https://www.who.int/news-room/fact-sheets/detail/ebola-virus-disease

https://en.wikipedia.org/wiki/Ebola_virus_disease

https://www.cdc.gov/vhf/ebola/index.html

https://www.cdc.gov/vhf/ebola/prevention/index.html

https://www.ncbi.nlm.nih.gov/genomes/GenomesGroup.cgi?taxid=186536

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