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PRiSM
Predicting Removal of Ionic, Small Molecules
PRiSM
Predicting Removal of Ionic, Small Molecules
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Kristin Barringhaus
Systems Engineer
Sara Smith
Mechanical Engineer
Christina Bagnati
Electrical Engineer
Marisa Hughes
Electrical & Software Engineer
Patient Story
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Acute Kidney Injury (AKI)
Continuous Renal Replacement Therapy (CRRT)
Impact
5% of all ICU patients develop AKI [1]
200,000 patients every year in the US [1][2]
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50% mortality rate for these patients [1]
Protein Polarization
Proteins
[3]
Dialyzer Fibers
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Normal Clearance
Total Occlusion
Meet PRiSM
Monitoring System
Clearance
Concentration
Impedance
Ultrafiltrate Flow Chamber
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Concentration
Arterial Flow Chamber
Impedance
Flow Chamber
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Monitoring System
Adequate
Inadequate
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Total Market of AKI Patients on CRRT
$16.9 billion
Global kidney dialysis equipment market [4]
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$745 million
$4.3 billion
CRRT Market [6]
Total AKI Market [5]
Summary
Clinical Need
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Monitors clearance of small molecules
200,000 patients impacted
Acknowledgements
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Stephen Ash, MD, FACP
HemoCleanse Technologies, LLC and Ash Access Technology, Inc.
William Clark, MD
Director, Professional Master’s Program
Davidson School of Chemical Engineering
Tom Sullivan
Electrical Engineer partner with Dr. Ash
Orlando Hoilett
Biomedical Engineering PhD Student
Fresenius Medical Care
Donation of dialyzers