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- also known as Heck’s disease,
- infrequent asymptomatic condition,
- caused by human papilloma virus- HPV infection in the mouth,
- histopathologic assessment and clinical observation are necessary to establish the diagnosis,
- is more common among younger age groups.
- has been reported worldwide,
- particularly common in small native communities (North, Central and South American Indians and Inuit)
- Incidence 30% has been reported among Inuit and children from some communities in Venezuela,
- it’s rare among Caucasian populations.
The most common sites of involvement include:
Multiple lesions on buccal and labial mucosa.
Pictures source: Ghalayani P,, Tavakoli P,, Eftekhari M,, et al. Oral focal epithelial hyperplasia: Report of three cases/oral fokal epitel hiperplazisi: Üç Olgu Sunumu. Turk J Pathol. 2015;31((1):):60-–63.
Source: Scully C., Scully's Medical Problems in Dentistry, Churchill Livingstone, 2014.
- living conditions (communal lifestyles)
- malnutrition,
- poor hygiene,
- genetic factors
- associated with HIV infection/AIDS.
Acanthosis of the epithelium with broad and elongated rete ridges.
Isolated perinuclear cellular vacuolization.
Mitosoid cell
1. Scully C., Scully's Medical Problems in Dentistry, Churchill Livingstone, 2014.
2. Ghalayani P,, Tavakoli P,, Eftekhari M,, et al. Oral focal epithelial hyperplasia: Report of three cases/oral fokal epitel hiperplazisi: Üç Olgu Sunumu. Turk J Pathol. 2015;31((1):):60-–63.
4. Durso BC, Pinto JMV, Jorge J Jr, de Almeida OP. Extensive focal epithelial hyperplasia: Case report. J Can Dent Assoc 2005; 71: 769–771.
3. Website: https://dermnetnz.org/topics/focal-epithelial-hyperplasia/