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Increase cardiac output/blood flow
Maintain vasomotor tone of local vascular beds
Increase oxygen and nutrient delivery
Maintain steady cerebral blood flow
BP =
Cardiac output (CO)
x systemic vascular resistance (SVR)
Target MBP = gestation (little evidence to support when recommended by BAPM in 1992)
Targeting a number does not tell you whether you need to address CO or SVR
No consideration for underlying pathophysiology
No consideration for compensatory mechanisms, cardiac function or fluid status
CO = stroke volume x heart rate
SVR determined largely by smooth muscle cells lining the arterioles
Autonomic nervous system has a pivotal role via adrenergic receptors located on cell membranes of smooth muscles in the vasculature and myocardial cells
Risk 1
Risk 2
Risk 4
Risk 3
Belong to the family of G protein coupled receptors