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Cell-city
An interactive game to revise cell-biology topics
University of Surrey-Giovanna Nalesso
DATE 19/12/19
The nucleus
Question 1
A nucleosome is made up of DNA and a histone core. How many proteins make up the histone core?
A) 2
B) 4
C) 6
D) 8
Question 2
What type of Chromatin is typically transcribed?
A) Euchromatin
B) Heterochromatin
Question 3
Does the leading DNA strand undergo discontinuous replication?
a) True
b) False
The plasma membrane
What is the role of cholesterol within the phospolipid bylayer?
Question 1
a) It makes it more fluid
b) It makes it more rigid
c) It allows receptors to anchor to the membrane
d) It drives lipid endocytosis
Once a receptor has engaged with its ligand:
Question 2
a) It dissociate from the plasma membrane
b) It travels across the plasma membrane
c) It changes the structure of the ligand
d) Changes shape
Which one is the slowest cell-to-cell type of communication?
Question 3
a) Paracrine
b) Autocrine
c) Endocrine
d) Synaptic
The ER and GOLGI apparatus
Question 1
A protein need to be modified before being secreted in the extracellular environment. Which one is the correct order of intracellular events allowing this process?
A. Postranslational modification in the ER-transit in the Golgi apparatus-vesicle budding- release in the extracellular environment through a clathrin-mediated fusion with the ECM
B. Postranslational modification in the Golgi-transit in the ER-endosome formation- release in the extracellular environment through a clathrin-mediated fusion with the ECM
C. Postranslational modification in the ER-transit in the Golgi apparatus-vesicle budding-release in the extracellular environment through a COPII-mediated fusion with the ECM
D. Postranslational modification in the Golgi-transit in the ER-endosome formation- release in the extracellular environment through a COPII-mediated fusion with the ECM
Question 2
Which protein/s mediate the the fusion of vesicles with their target organelles?
A) CLATHRIN
B) COPII
C) COP I
D) SNARE
Question 3
Which one is NOT a function of the GOLGI apparatus
A) Carbohydrate synthesis
B) Lipid synthesis
C) Protein sorting
D) Protein glycosylation
The Lysosome
Question 1
What is the pH within the lysosome?
A) 5
B) 7
C) 9
D) 12
Question 2
The enzymes present in the Lysosome are called hydrolases.
TRUE or FALSE?
Question 3
How is the acidic pH maintained in the Lysosome?
A) G-protein receptors
B) ion channel
C) gap junction
D) proton pump
The cytoskeleton
Question 1
Which filament of the cytoskeleton is made of dimeric subunits?
A) Actin filaments
B) Microfilaments
C) Intermediate filaments
D) Microtubules
Question 2
Max is a 5 year old labrador who has been diagnosed with prostate cancer. His veterinarian decided to prescribe a chemoterapic preventing cell division. Which cytoskeleton components is the drug likely to interact with?
A) Microtubules
B) Actin filaments
C) Intermediate filaments
D) Catenin/cadherin bonds
Question 3
What happens when cytoskeleton filaments reach the steady state equilibrium?
A) The speed of filament formation is = to filament destruction
B) the speed of filament formation is greater than that one of filament destruction
C) the speed of filament destruction is greater than that one of filament polymerisation
C) No filament can form because there are no monomers available in the cytoplasm
The mitochondrium
Question 1
How do you call the compartment enclosed by the inner membrane?
A) Cristae
B) Matrix
C) Intermembrane Space
D) Cytosol
Question 2
Mitochondria contain their own DNA and ribosomes.
A) True
B) False