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Presented by WeiJun VanLith
Born on May 28th, 1942 in Des Moines, Iowa. He spends most of his childhood in Des Moines, Iowa, and Cincinnati, Ohio.
Walnut Hills High School
University of Pensylvania
University of Pensylvania School of Medicine
University of California, San Francisco
National Institute of Health (NIH)
Staff member of UCSF after completing his residency in 1974.
In 1999, he became the director of the institute for Neurodegenerative Diseases research laboratory at UCSF.
Studied the surface fluorescence of brown adipose tissue in Syrian golden hamsters under Britton Chance during 2nd year of medical school.
Studied the metabloism of isolated brown adipose tissue under Olov Lindberg at Wenner-Gren Institute of Stockholm during 4th year of medical school.
Studied scrapie agent at UCSF in July 1974 after he was offered an associate professor position in the Neurology department.
High risk pertaining to scrapie studies due to assay problems.
Initial grant was written under glutamate metabolism.
Withdrawal of support from the Howard Hughes Medical Institute (HHMI)
Data suggested the scrapie agent contains proteins instead of nucleic acids.
Prushiner won the 1997 Nobel prize in medicine and physiology for the discovery of prion.
Initial finding was controversial within the scientific community.
In 1984, Leroy Hood sequenced a portion of amino acids in prion
It was revealed that the protein of prion was derived from a normal protein encoded by PrP gene.
Prion replication is a complicated process
Normal PrP is found in a helical shape, whereas the disease-associated form exists as a flattened sheet.
Why did I pick him?
How has my perception has changed as a result of my study?
“Alzheimer's Disease.” Mayo Clinic, Mayo Foundation for Medical Education and Research, 19 Feb. 2022, https://www.mayoclinic.org/diseases-conditions/alzheimers-disease/symptoms-causes/syc-20350447.
Norris, Jeffrey. “UCSF's Stanley Prusiner Named to Receive the 1997 Nobel Prize in Physiology or Medicine.” UCSF's Stanley Prusiner Named to Receive the 1997 Nobel Prize in Physiology or Medicine | UC San Francisco, 6 Oct. 1997, https://www.ucsf.edu/news/1997/10/131436/ucsfs-stanley-prusiner-named-receive-1997-nobel-prize-physiology-or-medicine.
“Prusiner Wins Nobel for Prions.” Science, 6 Oct. 1997, https://www.science.org/content/article/prusiner-wins-nobel-prions.
Prusiner, Stanley B. “The Nobel Prize in Physiology or Medicine 1997.” NobelPrize.org, 1998, https://www.nobelprize.org/prizes/medicine/1997/prusiner/facts/.
“Stanley B. Prusiner, MD.” Stanley B. Prusiner, MD | Institute for Neurodegenerative Diseases, https://ind.ucsf.edu/ind/aboutus/faculty/prusiners.