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chlordiazepoxide

Leo Sternbach

1934

1934

synthesis of tricyclic compound [heptoxdiazines]

1952

1952

commercialization of [clorpromazine] in France.

1954

1954

Sternbach decided to continue the studies on tricyclic compounds [heptoxdiazines]

1955

1955

Development of 40 new compounds with structural similarity to clorpromazine but results were negative.

1957

1957

Twist of chance

Ro 5-0690 was submitted for testing

Results came back POSITIVE

the synthisis

The synthesis

1958

1958

[chlordiazepoxide] was patented by Sternbach

TIMELINE OF CHLORDIAZEPOXIDE DISCOVERY

Development of 40 new compounds

commercialization of [clorpromazine]

[Clordiazepoxide ] was patented

1958

1955

1952

the discovery

synthesis of [heptoxdiazines]

1934

continue the studies on tricyclic compounds.

1957

find and test Ro 5-0690

1954

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