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While both package and contain materials within cells, a vacuole's main function is storage and a vesicle's main function is transport. They also each have their own more specific functions, roles, and locations.
A vacuole is a membrane-enclosed organelle in eukaryotic cells that can function for the storage and release of macromolecules, water retention, structure of the cell, reproduction, and catabolism. (pg. 63)
The vacuole is a compartment within the cell, which contains water or waste products, that can interact with other parts of the cell, like the cell wall. The plant's cell wall resists the swelling of a vacuole, and causes the cell to stiffen.
A contractile vacuole's function is to get rid of the excess water that rushes into the cell due to the imbalance in solute concentration inside and outside of the cell.
It enlarges as water enters, abruptly contracts, and forces the water out of the cell through a special pore structure.
It is found in many freshwater protists.
A vesicle is a tiny membrane-surrounded droplet that transports substances to the other organelles within a cell, or transports substances outside the cell.
A vesicle is a compartment that shuttles substances, like proteins, between the various components and parts of the endomembrane system. Vesicles transport substances from the Endoplasmic Reticulum to the Golgi Apparatus and from the Golgi Apparatus to the cell membrane, where they can then be exported outside of the cell. (pg. 65)