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Monophysitism started between 400 and 450 A.D. and ended in 451 A.D.
Monophysitism was rejected at the council of Chalcedon in 451.
Monophysitism is that in the person of Jesus Christ there was only one, divine nature rather than two natures, divine and human, as asserted at the Council of Chalcedon in 451.
Monophysitism was perhaps the most
controversial of the eastern christological
heresies.
Monophysitism started during the last decades of the Roman Empire. It was most popular in the Eastern Roman Empire, and particularly in Syria, the Levant, and Anatolia.