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McCune-Albright Syndrome

Symptoms

  • Early puberty, starting as early as 4-6 months
  • Polyostotic Fibrous Dysplasia (soft bone tissue)
  • Gigantism
  • Café-au-lait spots (pigmentation in the skin)

Skin Pigmentation

Cause

  • Caused by mutation in the GNAS1 gene
  • It is not inherited, so the mutation will not be passed through generations

Bone Deformities

Complicatons

In severe cases of MAS conditions may include:

  • Blindness
  • Deafness
  • Repeated broken bones
  • Tumors
  • Crushing's Syndrome

Gigantism

Prognosis

The lifespan for MAS is

relatively normal in moderate

cases. There have been some

reports of severe cases in which

the patient has died.

Treatment

There is not a specific treatment

for MAS, however some of the symptoms

will need to be treated with surgery or

hormone inhibitors.

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