Selective Serotonin Reuptake Inhibitors
(SSRIs)
- Zoloft 91 and Paxil 92
- Psychopharmacology
- Became stigmatized
- Bad prescriptions
- General care improving.
- New Pill: Prozac
- Released in 1987
- 1990 Prozac: most prescribed antidepressant
- First true SSRI (selective serotonin reuptake inhibitor)
- Became “get out of jail free card”
History
- First type: Tofranil
- Was released in 1958
- 60-70% success rate
- Original side effects
- Sluggishness
- Weight gain
- Death
Who Should Avoid SSRIs
- Discovery
- Discovered by chance
- Drug that controlled the neurotransmitters
- Munsterlingen Asylum
- Not so good for people with schizophrenia
Side Effects
Brief Overview of SSRI's
- People Allergic to SSRIs
- People taking other drugs such as MOAs
- Pregnant women
- Breastfeeding women
- People who drink alcohol
- Nausea
- Insomnia
- Dizziness
- Weight gain or loss
- Tremors
- Sweating
- Anxiety and restlessness
- Decreased sex drive
- Drowsiness or fatigue
- Dry mouth
- Diarrhea or constipation
- Headaches
Serotonin: Neurotransmitter, presynaptic neuron, postsynaptic neuron, reuptake
Depression: lack of Serotonin, presynaptic neuron, symptom of something else
Selective Serotonin Reuptake Inhibitors (SSRI's): control symptom's of depression, block, may not work due to many things, simply part of the cure
Black Box Label Warning
Don't Mix SSRIs with...
- Monoamine Oxidase Inhibitors (MAO)
- Tramadol
- Zyvox
- Alcohol
Created by Peter "The Brains" Orlando, Becca "The Glue" Bomgardner, Megan "The Face" Marrie and Anna "The Prezi" Haas
Prozac:
+ Generic name is fluoxetine
+ Approved to treat major depressive disorder in 1987 by the FDA
+ Third-most prescribed antidepressant in the US
+ Used to treat major depressive disorder, OCD, PTSD, bulemia nervosa, panic disorder, as well as obesity, alcohol dependence, and binge eating disorder
Types of SSRIs
Three most commonly used SSRIs:
1) Prozac
Zoloft:
2) Zoloft
+ Generic name is Sertraline
+ Approved in 1991 to treat major depressive disorder by FDA
+ Second-most prescribed antidepressant in US
+ Works better than Prozac to treat some subtypes of depression
+ Used to treat social phobias as well
+ Rated 4th in the top 10 antidepressants for effectiveness
3) Celexa
Celexa:
+ Generic name is citalopram
+ Approved to treat major depressive disorder in 1998 by FDA
+ Most prescribed antidepressant in US
+ Ranks 5th in the National Institute for Health and Clinical Excellence Top 10 Antidepressants for Effectiveness and 4th for cost-effectiveness