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RAF Cancer Gene
1
Transcript
RAF
- Rapidly Accelerated Fibrosarcoma
- Fibrosarcoma: A tumor that derives from fibrous connective tissue.
A-RAF
- Involved in the transduction of mitogenic signals from cell membrane to nucleus.
- Serves as a regulator for myogenic differentation by inducing cell cycle arrest, the expression of muscle-specific proteins, and myotube formation.
- Mutations found in 60 different cancer lines
- However, may not cause cancer.
BRAF
c-Raf
- Involved in sending signals inside cells, which help in cell growth
- 2002, shown to be mutated in human cancers.
- Inherited BRAF mutations can cause birth defects.
- Mutations can also appear later in life and cause cancer as an oncogene.
- AKA: RAF1
- Similar to BRAF, it helps with cell growth by using cell signals
- Mutation can cause many different diseases.
- Can cause LEOPARD Syndrome. (Retarded Growth, Abnormal Genitalia, Deafness, etc..)
MAPK Cascade
RAF Kinase
- RAF kinases participate in the MAPK pathway.
- MAPK pathway is a chain of proteins in a cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell.
- Mitogen-Activated Protein Kinases.
RAF Family
- ARAF
- BRAF
- c-RAF
By: David Isbrecht
Works Cited
- http://en.wikipedia.org/wiki/C-Raf#Regulation_of_activity
- http://www.ncbi.nlm.nih.gov/pubmed/15676015
- http://www.genecards.org/cgi-bin/carddisp.pl?gene=ARAF
- http://en.wikipedia.org/wiki/Raf_kinase
- http://en.wikipedia.org/wiki/BRAF_(gene)
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