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1981 – Transgenic mice and fruit flies are produced. Mouse embryonic stem cell line established.
1995 – Tsien identifies mutant of GFP with enhanced spectral properties
1998 – Mice are cloned from somatic cells.
1999 – Hamilton and Baulcombe discover siRNA as part of post-transcriptional gene silencing (PTGS) in plants
1939 – Siemens produced the first commercial transmission electron microscope.
1952 – Gey and coworkers established a continuous human cell line.
1955 – Eagle systematically defined the nutritional needs of animal cells in culture.
1957 – Meselson, Stahl and Vinograd developed density gradient centrifugation in cesium chloride solutions for separating nucleic acids.
1965 – Ham introduced a defined serum-free medium. Cambridge Instruments produced the first commercial scanning electron microscope.
1976 – Sato and colleagues publish papers showing that different cell lines require different mixtures of hormones and growth factors in serum-free media.
1595 – Jansen credited with first compound microscope
1655 – Hooke described 'cells' in cork.
1674 – Leeuwenhoek discovered protozoa.
1833 – Brown described the cell nucleus in cells of the orchid.
1838 – Schleiden and Schwann proposed cell theory.
1840 – Albrecht von Roelliker realized that sperm cells and egg cells are also cells.
1856 – N. Pringsheim observed how a sperm cell penetrated an egg cell.