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Aditya Desai
There is a problem with the understanding of genomic trends and their role in modulating cancer cachexia.
Despite a relatively more structured understanding of the effect of cancer cachexia on skeletal muscle and fat, the effect of cancer cachexia on gene signalling pathways has been thoroughly studied.
No fundamental research on genomic trends is occuring. There are a limited number of scientific publications on this topic. Of the little research available, none of it is specific to the trends correlated with cancer cachexia.
This problem has negatively impacted patients suffering from cancer cachexia because of the limited knowledge on this topic and the lack of clinical understanding/applications.
A possible source of this problem could be genomic differences in patients suffering from cancer cachexia that modulate cachectic symptoms.
Perhaps a study which investigates genomic trends and their role in cancer cachexia by analysis of TCIA and TCGA could provide more clarity in this situation.
What role do genomic trends play in the modulation of cancer cachexia as assessed by a thorough analysis of clinical data?
Cancer Cachexia - a multifactorial syndrome defined by an ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support and leads to progressive functional impairment (Fearon, et. al., 2011)
Atrophy - the wasting or breakdown of tissue, typically due to degeneration of cells
Genome - the complete set of genes or genetic material present in a cell or organism
Fearon, Lancet Oncol 2011
The Cancer Genome Atlas
The Cancer Imaging Archive
*Note: Once research is underway, more sources to be added