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Pain-Insensitivity Syndrome
Transcript
PAIN-INSENSITIVITY SYNDROME
Description:
-congenital insensitivity to pain aka congenital analgesia
-person can not feel/has never felt physical pain
-sensations are otherwise normal
-still feel touch, not always temperature
-no physical abnormalities
-many children die because dont feel any pain even if they are severly injured
Treatments:
-do not work
-some cases use naloxone which is a chemical that acts within the nervous system
-blocks nervous system from causing the interractions that occur within the group of cells that receives the message to initate the sensation of pain, heat or cold
History:
-1930's it was attracted to medical attention
-disorder can be due to mutations in voltage gated sodium channel scn9a
Quality of Life:
-most babies dont live more than 3 years
-if you live over 3 years of age, you most likely wont make it past 25 years of age
-those who survive infant years have a high percentage of becoming mentally retarded
-paranoia
Extra:
-84 United States citizens have PIS
-or 1 out of 357,000 people
-most people don't live past 25
Other Implications:
-orthopedic manifestations
-recurrent fractures
-osteomyelitis
-other neuropathic joints
Implications:
-absence of response to injury
-abnormal autonomic responses to painful stimuli
-lack of responsiveness to stimuli
-retain ability to identify stimilus presence
-prevents nervous system from feeling pain, heat and cold
Causes:
-mutations in sodium channel
-leprosy can result in the progressive destruction of the nerves
-can be passed to offspring
-overproduction of brain endorphins which could be somehow interrelated to this disorder
Sources:
http://www.rightdiagnosis.com/c/congenital_insensitivity_to_pain_syndrome_intro.htm
http://serendip.brynmawr.edu/exchange/node/1736
http://medical-library.net/content/view/1691/41
Cause:
-mutations in sodium channel
-leprosy can result in the progressive destruction of the nerves
-can be passed to offspring
-overproduction of brain endorphins which could be somehow interrelated to this disorder
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