Glycostat® Wild Bitter Melon

Clinical Trials/Study

1) Findings in Acute Diabetic and Non-diabetic Animal Model

- extracts administered at the rate of 250 mg/kg proved comparable to metformin administered at the rate of 150 mg/kg.

2) Other studies

- Glycostat was superior to Chinese and Indian preparations with regard to glucose metabolism

- Lower cholesterol

- both the Chinese and Glycostat arms exhibited significantly lower circulating glucose

- Suppress inflammation

CONCLUSION

Men behind Glycostat®

(Glykon Scientific Advisors)

THANK YOU

WHY Glycostat Bitter Melon?

Glycostat® Wild Bitter Melon

Limitations

Fresh bitter melon extracts are clinically active in humans

However...

Glucose tolerance test (GTT) in control Bitter Melon (BM) extracts, China BM, India BM, and Glycostat BM groups

Stable delivery dosage

Problematic, inconsistent

Glycostat

more stable/superior to other extracts.

Glycostat® demonstrated statistically significant results after a glucose tolerance test in healthy rats, whereas the other two leading bitter melon extracts did not.

Blood Pressure

In comparison to two other leading bitter melon extracts, Glycostat® demonstrated statistically significant results for parameters related to blood pressure, whereas the others did not.

-This suggests that neither the bitter melon's “bitters” nor charantins are responsible for these blood glucose lowering effects alone as is often claimed about bitter melon extracts.

-Rather, additional constituents concentrated and preserved in Glycostat® are critical to this activity.

This also shows, the additional constituents concentrated and preserved in Glycostat® are critical to this activity.

Common Types

Chinese type

Indian type

Benefits

- A vegetable with pantropical distribution

- contains substances with anti-diabetic properties & bioactive components (antioxidants)

- Improves glucose disposal

- Supports insulin sensitivity and insulin-like actions

- Comparable or superior to the drug Metformin in glucose disposal

- Increases nutrient uptake

- Supports greater beta-oxidation of fats

Effective Dosage

minimum dosage: 750mg

(adapted from; Jarrow Formulas Pressure Opti)

Bitter Melon: A Dietary Approach?

WHAT is Bitter Melon??

- Avoided by patients with a known allergy/hypersensitivity to bitter melon

- should NOT be consumed during pregnancy/lactation

- wide variations in preparation techniques; BUT optimum dosage not known

- Momordica charantia

- also known as Bitter Gourd, Bitter squash or Balsam-pear, Goya (Okinawan) or Karela (Sanskrit)

WHY Glycostat??

Indian Wild Bitter Melon

Glycostat bitter melon

Regular bitter melon

• Glycostat® extract relies upon a proprietary stabilization process to retain the activity of fresh bitter melon.
• Glycostat® actually has the color and taste of bitter melon.

OTHER FINISHED PRODUCTS

Fat burner

Blood pressure

Blood glucose

Immune system

Juice/beverage

Supplements

So WHY is it SELLING so well in US?

“Quite frankly, I had not expected this HCA product to work. You may remember that I have had considerable experience with other commercially available sources of HCA, none of which had any effect, other than that of a placebo, upon appetite and weight. For this reason, I have been quite pleasantly surprised by the very significant appetite reduction induced by Glykon's HCA. "

-Mark L. Saginor, M.D., D.H.M.

Assistant Clinical Professor

U.C.L.A. Medical School

Personal physician to Pres. Ronald Reagan

• Professor of Medicine and Pathology, Georgetown University Medical School.
• Current (and twice past) President of the American College of Nutrition.
• Profiled in MARQUIS Who's Who

Mark Saginor, MD

• Dr. Clouatre is a widely published researcher and author in the field of alternative medicine / nutrition.
• He has published a number papers in professional medical peer-reviewed journals.
• World Health Organization (WHO) selected authority on Kava-kava toxicity.

• Co-Inventor of Ten Glykon Patents
• 1982 International "Men of Achievement" 9th Edition
• 1982 "Personalities of America" 2nd Edition
• 1994 Marquis "Who's Who in Business and Finance" 26th Edition
• 1994 Marquis "Who's Who in the World" 9th Edition
• 1994 Marquis "Who's Who in the West 23rd Edition
• 1995 Marquis "Who's Who in Science and Engineering" 2nd Edition
• 1999 Marquis “Who’s Who in Medicine and Healthcare” 2nd Edition

Dallas L. Clouatre, Ph.D.

Kevin M. Connelly, Ph.D.

Ph. D., Biochemistry and Molecular Biology

University of California, Los Angeles, CA (UCLA

Brad J. Douglass, Ph.D.

Ph. D., Synthetic Organic Chemistry

University of Southern California (USC)

JAMES M. DUNN, M.D.,