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*Adaptive immune response
*Primary infection.
Most of effector T cells die, and the rest becomes memory cells for a secondary infection.
1- Effector memory T cells.
They are found in the circulation.
They interact with a specific viral antigen.
2- Central memory T cells
They are found in lymphoid tissues.
They act as a storage of memory cells.
T cells detect processed viral peptides.
* APCs
CD4( T helper cell) recognizes MHC II.
* Most cell types
CD8 (cytotoxic T cell) recognizes MHC I.
Anna Marie Skalka, Glenn F. Rall, Jane Flint, Lynn W. Enquist, Vincent R. Racaniello. 2015. Principles of Virology - 4th Ed. Washington, DC. American Society for Microbiology
They recognize extracellular antigens such as antigens in bloodstream and at mucosal surfaces.
B cells are differentiated to plasma cells and memory cells.
figure 4.6 Principles of Virology 4th
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