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Immunological Function Of The Thymus

Skin Grafting

testing recognition of self

  • Ak mice receive C3H grafts

  • C3H mice receive Ak grafts

Lymphocyte Polymorph Ratio

spleen difference

2 Hypotheses

Testing it out

1. The thymus does not participate in immune reactions - it has little or no effect on antibody production

2. Thymus somehow partakes in the control of immune response - functions in acute infections when antibodies are most needed.

germinal centers in the spleen

  • mice thymus removed

1- 16 hours after birth

  • sham-thymectomised mice

underwent surgical procedure

but thymus remained intact

  • mice thymus removed

at 5 days of age

* no antibiotics were used

Thymus: Function Unknown

question: If it was so important in immune response why would it disappear as we age?

Thymus role is to control the immune system

thymus control

Hypothesis 1

No Antibody Production

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