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Optibor / Sassolite / Boric Acid

H

O

Chemical and Physical Properties

Biomedical effects

  • Boric acid is readily absorbed from GI tract, serous cavities, and abraded or inflamed skin. It does not penetrate intact skin.
  • 90%-95% of the administered dose is cleared/eliminated from the blood via excretion, regardless of the route of administration.
  • Boric acid is predominantly eliminated, unchanged, by the kidney. Small amounts are also excreted into sweat, saliva, and feaces. Boric acid is concentrated in the brain and liver.
  • Increased level of boric acid is coupled with riboflavin-urea ( High riboflavin level in urine ).

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Pharmacology

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  • Chemical formula = H3BO3
  • Molecular Mass = 61.83
  • Colourless and Odourless
  • Melting Point = 170.9°C
  • Faintly Bitter
  • Water souluble
  • Volatile with Steam
  • Solubility increased in water by adding HCl

Pharmacokinetics

Medicinal Significance

  • Aqueous solutions of boric acid are used topically for ophthalmic irrigation to cleanse, refresh, and soothe irritated eyes.

  • Posseses weak fungistatic / Bacteriostatic properties, thus also employed in Otic preparations.

  • Used in the treatment of Vulvovaginal candidiasis.

  • Used in the treatment of cutaneous mycosis i.e, Athelete`s foot.
  • Experimental studies have shown that 90-95% boric acid administered is excreated out of the body via renal clearance !

  • Clinical researches show that 21 Hours is the estimated half life of boric acid !

Pharmacology

Pharmacodynamics

  • Caused changes in the lipid metabolism,
  • Changes in the water-mineral balance of the organism,
  • Changes in the Acid-base equilibrium of the blood,
  • No effect on the morphology,
  • No effect on the carbohydrate and protein metabolism.

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Dosage Forms

  • alcohol solution (from 0.5% to 5%) - Otic preparations;
  • 10% glycerol solution of boric acid - used to treat diaper rash and bed sores;
  • Salido-lovoy ointment for peeling / keratinolysis;
  • Teymu-rova paste for excessive sweating and as an antiseptic.
  • Intra-vaginal gelatin capsules are used to cure vulvovaginal candidiasis .

Adverse Effects

  • Acute Boric Acid poisoning is followed by :- vomiting, diarrhoea, abdominal pain,
  • erythematous rash involving both skin and mucous membranes,
  • followed by desquamation, and stimulation or depression of the central nervous system.
  • There may be convulsions and hyperpyrexia. There may also be renal tubular damage.

Over Dosage

In case of over dosage, Peritonial or Heamodyalais is refferred

Learning Objectives

Dosage

  • Occurance
  • Chemical / Physical properties
  • Pharmacology
  • Medicinal Significance
  • Biomedical Effects and Toxicity
  • Dosage forms / Mode Of Administeration
  • Adverse Effects
  • Dose

Occurance

  • Boric acid can be found in free state near volcanic regions.

  • They may also be found in the forms of minerals, such as borax, colemanite etc.

  • Boric acid is also found in various fruits and vegetables

The following doses have been studied in scientific research:

BY MOUTH:

There is no Recommended Daily Allowance (RDA) for boron since an essential biological role for it has not been identified. People consume varying amounts of boron depending on their diet. Diets considered to be high in boron provide approximately 3.25 mg of boron per 2000 kcal per day. Diets considered to be low in boron provide 0.25 mg of boron per 2000 kcal per day.

The Tolerable Upper Intake Level (UL), the maximum dose at which no harmful effects would be expected, is 20 mg per day for adults and pregnant or breast-feeding women over 19 years of age. For adolescents 14 to 18 years of age and pregnant or breast-feeding women 14 to 18 years of age, the UL is 17 mg per day. For children 9 to 13 years old, the UL is 11 mg per day; children 4 to 8 years old, 6 mg per day; and children 1 to 3 years old, 3 mg per day. A UL has not been established for infants.

VAGINALLY:

For vaginal infections: 600 mg of boric acid powder once or twice a day.

For prevention of recurring Candida (yeast) infections: 600 mg twice weekly.

Boric Acid occurance in different foods

Apple, red with peel 2.38-2.73mg/kg

Banana, 3.72mg/kg

Almonds 23mg/kg

Peanuts 13.8-18mg/kg

Beer 0.13-1.8 mg/L

Enriched white bread 0.20-0.48mg/kg

Instant white rice ≤0.015mg/kg

Toxicity

  • Research has led us to conclude that high level of boric acid toxicity may cause dermal vasodialation, mild perivascular inflammation.
  • Dermatologic effects include erythema, desquamation, exfoliation, Boiler Lobster syndrome etc.
  • Erythema may be prominent on the buttocks and scrotum.
  • Ingesting, 2000-3000 mg for infants 5000-6000 mg for children and 15,000-20,000 mg for adults, is fatal !

Presented By Group H

#64 Sadaf Mushtaq

# 65 Shahzain Khan

# 66 Sana Rahim

# 67 Saba Mariyam

# 68 Maira Khan

# 69 Talha Sadiq

# 70 Hafsa Rizvi

# 71 Narmeen Tariq

# 72Hassam Shahid

Muchas Gracias

;)

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