In the Name of God
Synthesis of Creatine Supplement
Dr. Alemzadeh
Moein Mahmoudi
Mahbod Mortazavi
Structure & Properties
Solubility Creatine dependence in Water?
Temperature?
Concentration?
PH?
Chemical synthesis of creatine
- Creatine Synthesis from Sarcosinates and Cyanamide
Washing solvent: hot water
Drying: hot temperature in vacuum dryer
- Creatine Synthesis from Sarcosinates and O-alkylisourea
Washing solvent: Water & Alcohol
- Creatine Synthesis from Sarcosinates and S-alkylisothiourea
(N-methylglycinate + HCl) @ T~15 & PH~9.5
S-alkylisothiourea @ T~30
Washing solvent: Water & Acid & Alcohol
Improving creatine solubility
Drying the hydrated mixture
Creatine supplement powder with high solubility
Photometric Determination Methods for Creatine
Methods for Creatine Determination
Enzymatic Analysis of Creatine
Chromatographic Methods for Creatine Determination
H-NMR
NMR Spectroscopy of Creatine
IR-spectroscopy of creatine
C-NMR
P-NMR
History
- has a positive influence on cholesterol metabolism.
- It can active the immune system and reduces the risk of cancer.
- Together With other antioxidants such as carotenes, glutathiones and vitamin E, ascorbic acid acts as a scavenger for free radicals and oxidiZing species of oxygen.
- Ability to regenerate vitamin E.
- It's reversibility oxidation to dehydro-L-ascorbic acid.
- It is prophylactic and therapeutic properties for the treatment of various diseases.
(Creatine + Ascorbic Acid) @ T=-10_90 C
+
in the presence or absence
of a solvent or diluting agent (alcohols, ethers, ketones ,...)
+
Water
+
(other substances such as
pharmaceutical formulation additives, vitamins, mineral substances, trace elements, carbohydrates)
=
Creatine supplement
creatine supplement = creatine + L-Ascorbic Acid
Gastrointestinal distress
synthesis of creatine supplement
Body weight and water retention
Synthesis of solid creatine
Some method for synthesis of solid creatine:
- Creatine monohydrate + aqueous polyvinylpyrrolidone
- creatine dosage forms are in the form of two-piece gelatin capsules
- A mixture Which comprises at least one thermoplastic, physiologically tolerated, Water-soluble or Water sWellable polymeric binder and creatine, and contains 1 to 20 mol of Water per mol of creatine is prepared.
- The mixture is plasticated at or above the softening point of the polymeric binder, preferably With at least partial evaporation of the Water.
- The plasticated mixture is shaped to dosage forms and cooled.
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