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Transcript

In the Name of God

Synthesis of Creatine Supplement

Dr. Alemzadeh

Moein Mahmoudi

Mahbod Mortazavi

Structure & Properties

Solubility Creatine dependence in Water?

Temperature?

Concentration?

PH?

Chemical synthesis of creatine

  • Creatine Synthesis from Sarcosinates and Cyanamide

Operating conditions:

Washing solvent: hot water

PH~10

T~80 c

Drying: hot temperature in vacuum dryer

Yield:

75%

  • Creatine Synthesis from Sarcosinates and O-alkylisourea

Operating conditions:

T~ 5-25 C

PH~ 10-12

Washing solvent: Water & Alcohol

Yield:

75%

Operating Conditions:

  • Creatine Synthesis from Sarcosinates and S-alkylisothiourea

(N-methylglycinate + HCl) @ T~15 & PH~9.5

Mixer

S-alkylisothiourea @ T~30

Washing solvent: Water & Acid & Alcohol

Yield:

75%

Improving creatine solubility

Creatine + Protein

Drying the hydrated mixture

Creatine supplement powder with high solubility

Photometric Determination Methods for Creatine

Methods for Creatine Determination

Enzymatic Analysis of Creatine

Chromatographic Methods for Creatine Determination

H-NMR

NMR Spectroscopy of Creatine

IR-spectroscopy of creatine

C-NMR

P-NMR

History

  • has a positive influence on cholesterol metabolism.
  • It can active the immune system and reduces the risk of cancer.
  • Together With other antioxidants such as carotenes, glutathiones and vitamin E, ascorbic acid acts as a scavenger for free radicals and oxidiZing species of oxygen.
  • Ability to regenerate vitamin E.
  • It's reversibility oxidation to dehydro-L-ascorbic acid.
  • It is prophylactic and therapeutic properties for the treatment of various diseases.

(Creatine + Ascorbic Acid) @ T=-10_90 C

+

in the presence or absence

of a solvent or diluting agent (alcohols, ethers, ketones ,...)

+

Water

+

(other substances such as

pharmaceutical formulation additives, vitamins, mineral substances, trace elements, carbohydrates)

=

Creatine supplement

creatine supplement = creatine + L-Ascorbic Acid

Gastrointestinal distress

Renal dysfunction

synthesis of creatine supplement

Dehydration

Mood and anxiety

Body weight and water retention

Synthesis of solid creatine

POTENTIAL IMPURITIES

Some method for synthesis of solid creatine:

  • Creatine monohydrate + aqueous polyvinylpyrrolidone
  • Melt calendering
  • creatine dosage forms are in the form of two-piece gelatin capsules

Drying

Casting

Common method

  • A mixture Which comprises at least one thermoplastic, physiologically tolerated, Water-soluble or Water sWellable polymeric binder and creatine, and contains 1 to 20 mol of Water per mol of creatine is prepared.
  • The mixture is plasticated at or above the softening point of the polymeric binder, preferably With at least partial evaporation of the Water.
  • The plasticated mixture is shaped to dosage forms and cooled.

Thanks to...

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