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Isaacs-Mertens

Syndrome

Carley Vento & Miles Easland

Isaacs syndrome (IS; also called neuromyotonia) is a neuromuscular disorder in which the peripheral nerves are hyperexcitable, resulting in spontaneous and prolonged muscle contraction.

Neuromuscular = relating to nerves and muscles

Peripheral Nervouse System = consists of the nerves outside of the brain and spinal cord. The main function of the PNS is to connect the central nervous system (CNS) to the limbs and organs

Hyperexcitable = the state or condition of being unusually or excessively excitable

Autoimmune = relating to disease caused by antibodies produced against substances naturally present in the body

  • Typically affects limbs
  • 15-60 year olds
  • Generally an autoimmune condition
  • Some forms are hereditary
  • Abnormal voltage-gated potassium channel

(VGKC) function

  • Can occur while sleeping or anesthetized
  • Symptoms:

Stiffness/twitching

Cramping

Increased sweating

Delayed muscles relaxation

Weakened reflexes

Numbness uncommon

Can also affect speech

Biological

Not

Cognitive

or

Socioemotional

Causes

Prognosis:

No Cure

Treatment:

Drugs - Benzodiazepines,

Parkinson Drugs and Narcotics

Physical Therapy

Plasma Exchange

Organizations

National Organization for Disorders (NORD)

National Institute of Neurological Disorders and Stroke

Hereditary

Iron deficiency

Chronic Lung Disease

Anemia

Huntington's Disease

Diabetes

History of Autoimmune Disorder

Definitions

Overview

Prognosis:

No cure

Diagnosis

Treatment History

Conduct sleep study

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