Isaacs-Mertens
Syndrome
Carley Vento & Miles Easland
Isaacs syndrome (IS; also called neuromyotonia) is a neuromuscular disorder in which the peripheral nerves are hyperexcitable, resulting in spontaneous and prolonged muscle contraction.
Neuromuscular = relating to nerves and muscles
Peripheral Nervouse System = consists of the nerves outside of the brain and spinal cord. The main function of the PNS is to connect the central nervous system (CNS) to the limbs and organs
Hyperexcitable = the state or condition of being unusually or excessively excitable
Autoimmune = relating to disease caused by antibodies produced against substances naturally present in the body
- Typically affects limbs
- 15-60 year olds
- Generally an autoimmune condition
- Some forms are hereditary
- Abnormal voltage-gated potassium channel
(VGKC) function
- Can occur while sleeping or anesthetized
Stiffness/twitching
Cramping
Increased sweating
Delayed muscles relaxation
Weakened reflexes
Numbness uncommon
Can also affect speech
Biological
Not
Cognitive
or
Socioemotional
Causes
Prognosis:
No Cure
Treatment:
Drugs - Benzodiazepines,
Parkinson Drugs and Narcotics
Physical Therapy
Plasma Exchange
Organizations
National Organization for Disorders (NORD)
National Institute of Neurological Disorders and Stroke
Hereditary
Iron deficiency
Chronic Lung Disease
Anemia
Huntington's Disease
Diabetes
History of Autoimmune Disorder
Definitions
Overview
Prognosis:
No cure
Diagnosis
Treatment History
Conduct sleep study