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Microfluidic device "circulating tumor cells" from whole blo
Transcript
Microfluidic device "CTC" from whole blood samples
Benefits:
- Improve Detection of Circulating Tumor Cells
- "Liquid biopsy” could one day inform decisions about the right therapy at the right time
- CTC-iChip - monitoring & treating the disease more personalized.
Advantages & Disadvantages
What is microfluidics?
Disadvantages:
- expensive
- dependence
- small volumes, challenging subsequent analytical chemistry
- complex operational control and chip design
Advantages:
- portable
- low number of cells is sufficient
- easy to use
- fast
- reduce sample volumes
- flexibility of device design
- reduced reagent consumption
How to use:
- Get a blood sample from the patient
- After collecting a blood sample, mix the sample with tiny, magnetic beads coated with specific antibodies. In some cases, use antibodies that seek out and attach to CTCs, and in other cases they used antibodies that bind to white blood cells. This magnetic labeling would come into play later in the microfluidic sorting process.
Feasibility Percentage
Definition of Specification
90%
- The presence of CTCs in the blood can actually help healthcare providers to monitor whether a particular treatment is working.
- If the circulating tumor cell number goes up or down as the patients are on treatment, you would know very quickly from the blood test.
- In addition to monitoring CTC number in the blood, the DNA of circulating tumor cells can be analyzed to look for cancer-causing mutations, information that can be used by doctors to determine what medications may be most effective
Indication of use
- The ability to detect circulating tumor cells (CTCs) as they travel through the blood can play an important role in early diagnosis, characterization of cancer subtypes, treatment monitoring and metastasis. By measuring a patient’s CTC levels over time, clinicians can quickly determine if a particular cancer treatment is working.
Sources: http://www.sciencedirect.com/science/article/pii/S0956566314005302
http://www.nibib.nih.gov/news-events/newsroom/tiny-technology-enables-improved-detection-circulating-tumor-cells
http://www.nibib.nih.gov/news-events/newsroom/tiny-technology-enables-improved-detection-circulating-tumor-cells
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