紹介 

Prezi AI.

新しいプレゼンアシスタント。

これまで以上に短時間で、コンテンツをの質を上げ、強化、調整し、関連する画像を入手し、ビジュアルを編集できるようになりました。

ロード中…
テキスト

Isotype Switching

CD40 ligand deficiency leads to a lack of isotype/class switching and impairment of macrophage function

The process by which the B-cell changes the class of immunoglobulin it makes while preserving the antigenic specificity of the immunoglobulin

What is CD40 Ligand

Deficiency?

Impediment of CSR

Clinical Characteristics

Hyper IgM Syndrome

&

Macrophage Activation

Lack of GM-CSF

Symptomology:

Neutropenia

Common Symptoms include: upper and lower respiratory tract infections, chronic diarrhea, liver disease/inflammation, and neutropenia

Isotype Switching: CSR

Defects in both humoral and cell-mediated immunity

Detection:

Method 1: Flow Cytometry

Case Study 2: CD40 Ligand Deficiency

Reference

Method 2: Lymph node Biopsy

Geha, R., & Rosen, F. (2008). Case studies in immunology: A clinical companion (6th ed.). New York, New York: Garland Science, Taylor and Francis Group.

Parham, P. (2015). The immune system. Garland Science, Taylor & Francis Group, LLC. Fourth Ed. (London & New York).

http://www.bloodjournal.org/content/103/3/1152?variant=full-text&sso-checked=true

http://www.nature.com/nm/journal/v4/n11/pdf/nm1198_1253.pdf

http://www.ncbi.nlm.nih.gov/pubmed/9255191

http://adc.bmj.com/content/84/6/508.full

Sang Won Choi

Macaire Grobe

Questions?

Treatment Methods:

  • Short term:
  • Immunoglobulin Replacement Therapy
  • Long Term:
  • HSC Transplant
  • Gene Therapy

Case Study: Dennis Fawcett

Summary:

5 years old:

  • No antibody against strep and recurrent sinus infections
  • DPT booster did not work
  • Raised monocyte counts
  • Low IgA and IgG, but high IgM anti-A and anti-B antibodies
  • No follicles or germinal centers and no T-cell binding of soluble CD40

15 Years Old

  • Being treated with IV gamma globulin
  • Had complications in the liver (cholestasis, sclerosing cholangitis)

21 years old

  • died of liver failure

  • The CD40L protein is expressed after T cell receptor recognizes MHC complex on an antigen-presenting cell.
  • CD40-CD40L ligation is required to signal class switching of antibodies and the activation of certain macrophage functions.
  • Lack of diversity in immunoglobulin classes as well as impaired macrophage function leads to defects in both humoral and cell-mediated immunity.
Prezi を使ってダイナミックで魅力的なプレゼンを作成する方法