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skin lesions from dioxin-exposed humans with chloracne

Results/Conclusions

Methodology

p-EGFR and p-MAPK were found in all chloracne lesions, whereas no expression was found in the samples from the control group (P = 0.000) In the skin of the chloracne patients, p-EGFR was mainly distributed in the membrane and cytoplasm, especially in the vicinity of membrane; the major positive signal of p-MAPK was in the core and serosity.

Analysis

12 male chloracne patients who had worked in a Chinese factory where pentachlorphenol (PCP) was produced from hexachlorocyclohexane (HCH) before 2002. It has been shown that dioxins are impurities that are formed during the production process of PCP (Cheng et al., 1993).

All study subjects answered an occupational questionnaire and gave informed consent. The research protocol was approved by the Ethics and Research Committees of all participating institutions, and followed the tenets of the Declaration of Helsinki.

According to the routine dermatological practice procedures, local anesthesia with lidocaine was used in all subjects. The epidermal tissues were obtained by punch biopsies (Biopsy Punch, Waechtersbach, Germany) from the neck, back, and face for 3, 5, and 4 chloracne patients, respectively. The samples from the face were obtained by a fusiform incision in order to be sutured easily and to guarantee acceptable cosmetic appearance. All these 12 biopsies were from lesional skin. The tissues for the controls were taken from the same localizations by the same process. Every piece of skin was 5 mm × 2 mm in diameter × thickness. All biopsies were performed by an experienced surgeon. Immediately after the collection, the fresh biopsy samples were briefly washed in saline, snap-frozen and stored in liquid nitrogen.

I believe there was no bias in this study because it was straight forward and right to the point.

The Details

Toxicology Letters

Tang NJ, Liu J, Coenraads PJ, Dong L, Zhao LJ, Ma SW, Chen X, Zhang CM, Ma XM, Wei WG, Zhang P, Bai ZP.

April 2008

Occupational exposure to certain polychlorinated aromatic hydrocarbons such as dioxins has been suggested to cause chloracne. This is case study relevant to what is being studied.

Questions

Study type

This Study seemed the most relevant to my environmental health concern and my toxin because it had all of the answers

What are the blind spots to this study type?

What are the strengths to this study type?

The introduction of Dioxins into the environment is potentially linked to the health concern Chloracne.

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