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Nucleoproteins

Histones

  • Protein + Nucleic Acid
  • Examples: Ribosomes, nucleosomes, all viruses

Protamines

Glycoproteins

  • Water soluble proteins
  • Rich in ARGININE or LYSINE
  • Packages DNA

Scleroprotein

  • Water soluble
  • Low molecular Weight
  • Rich in ARGININE
  • Consists of 28 amino acids (19 arginines and 8-9 non basic amino acids)
  • Protein + Carbohydrate
  • Linkage between asparagines (Ans) and glucosamine
  • intracellular
  • important role in membrane interaction and recognition
  • secretory
  • plasma glycoproteins

Albumins

  • a.k.a. albuminoids
  • insoluble in all neutral solvents and dilute alkalis and acids
  • Fibrous proteins
  • Found in connective tissues and in hair and nails
  • Function: Provides protective and structural support in connective tissues

Functions

  • Essential for sperm head condensation
  • DNA stabilization
  • Medical:
  • Neutralizes anti-clogging effects
  • prevents obesity

Example

CONJUGATED PROTEINS

Keratin

  • Found in body cells and blood stream of vertebrate animals.
  • Water soluble
  • Moderately soluble in concentrated salt solutions
  • Denaturizes in heat

Globulins

Structure

Conjugated Proteins

Function

  • Binds: Water, cations, fatty acids, hormones , etc...

  • Function in serum albumin (55% blood proteins):
  • Regulate oncotic pressure (regulates water distribution)

Prolamines

  • Major blood protein (40%)
  • Produced in liver & immune system
  • Insoluble in water
  • Soluble in dilute salt solutions

Phosphoproteins

  • Contains a non-protein portion
  • non-protein portion known as the "prosthetic group" or the "cofactor"
  • Soluble in 70-80% alcohol
  • Found ONLY in PLANT material
  • Plant storage proteins containing high GLUTAMINE and PROLINE content
  • Protein + Phosphate
  • Phosphate group regulates protein function
  • Example: Casein (milk), ovovitelline (eggs)

Functions

Example

  • Primarily involved in defense mechanisms of the body
  • Also transport various substances

Types of Globulins

  • Alpha and beta globulins
  • mainly in liver
  • transport substances (hormones, cholesterol, and iron) in blood
  • Beta globulins can bind to lipid molecules (cholesterol)

  • Gamma globulins
  • produced by lymphocytes
  • Part of the body's defense system and fight pathogens

Hemoglobin

Lipoproteins

  • Proteins + lipids
  • HDL, LDL, lipoproteins, pre-B lipoproteins

Simple Proteins

Introduction

Glutelins

  • Contain only amino acids or their derivatives

  • Further classified according to their solubility
  • Soluble in dilute acids and alkalis
  • Occurs ONLY in PLANT material
  • Primary energy storage in rice
  • Simple Proteins
  • Conjugated Proteins

Chromoproteins

Examples

  • Protein + pigment

Plasma albumin

Collagen

Keratin

Metalloproteins

  • Protein + metal ion
  • Example: caeruoplasmin enzyme

CLASSIFICATION OF PROTEINS

ACCORDING TO THEIR COMPOSITION

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