Death from Within
Lymphoma
Sarah Burney
Howard Quach
Treatments for Hodgkin's Lymphoma
Stages of Primary Effusion Lymphoma
Primary Effusion Lymphoma
- Stage 1: One group of lymph nodes can occur anywhere or can occur in an organ
- Stage 2: Two sites show up on one side of the diaphragm
- Stage 3: Both sides show up on the diaphragm
- Stage 4: Many groups pop up everywhere
- Lymphoma:
- Stage 1: Same as HIV stages, you have to be tested, if HHV-8 shows up in a scan then you are positive for Lymphoma.
- 2-4 cycles of chemotherapy followed by radiation treatment to the initial site of lymphoma
- Optional: Chemotherapy therapy alone for 4 or 6 cycles
- Patient Doesn't Respond to Treatment: High-doses of chemotherapy followed by stem cell transplant
Stages III-IV
- More intense regimens of chemotherapy followed by radiation treatment
- Patient Doesn't Respond to Treatment: High-doses of chemotherapy and possibly radiation treatment
- Stem cell transplant recommended
Lymphoma:
- very limited treatment, there is really nothing you can do
Stage II
Symptoms
Primary Effusion Lymphoma
comes from HIV. Usually 4% of patients who have HIV will end up getting P.E.L. This Lymphoma arises in body cavities. Most people get Herpes before a cavity is found. This disease is noncuriable and has a very low treatment rate.
Location
Statistics
Stages of Hodgkin's Lymphoma
Anywhere along the Lymph system, body cavities, in a tumor, and in chest cavities.
Hodgkin's Lymphoma
Lymphoma:
- HIV symptoms
- Human herpes
- Build up of fluid
- Shortness of breathing
Hodgkin's Lymphoma:
- Painless swelling of lymph nodes in neck, armpits, and groin
- Persistent fatigue
- Fever and chills
- Night sweats
- Unexplained weight loss
- as much as 10% of body weight
- Loss of appetite
- Itching
- Increased sensitivity to effects of alcohol
- pain in lymph nodes after drinking alcohol
Stage I
Stage III
Most patients with Hodgkin's lymphoma have the classic type of lymphoma. This affliction consists of large, abnormal lymphocytes known as Reed-Sternberg cells. These cells typically occur throughout the body where lymph tissue can be found. Hodgkin's lymphoma is curable with a relatively high survival rate of 85.9% if detected early.
- Stage I: Lymphoma found in 1 group of lymph nodes or in 1 body organ.
- Stage II: Lymphoma found in 2 or more groups of lymph nodes OR an organ and 1 or more group of lymph nodes.
- 2 sites of lymphoma must be on the same side of the diaphragm.
- Stage III: Lymphoma on BOTH sides of the diaphragm.
- Stage IV: Lymphoma found in multiple groups of lymph nodes and has spread to organs such as the liver or lungs.
Hodgkin's Lymphoma:
- 85.9% survive past 5 years of diagnosis
- 2.7 per 100,000 new cases annually
- 3.0 males per 100,000 & 2.4 females per 100,000
- 0.4 per 100,000 deaths annually
- Median Age at Diagnosis: 38 y.o.
- Male Caucasians are among those with the highest risk of developing Hodgkin's Lymphoma
With Lymphoma: survival rate is around six months.
Causes
Specific types of cells that are effected
Stage IV
Lymphoma: B-cells and any cells that have a large nuclei
Hodgkin's Lymphoma:
- Mutation of B-cell lymphocyte DNA
- Infection of Epstein-Barr virus
- Leads to formation of Reed-Sternburg cells
Lymphoma: Anything that exposes the inside body parts during surgical procedures. Also any organ that is placed in your might be affected.