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By:

David Ten Bruggencate

John Hong

Paulina Kapela

Jason Lee

Ashley Payne

Lauren Swackhammer

The Renal System

Renal Capsule

Medulla

The Kidney

Renal Artery

Renal Column

TITLE

Renal Vein

Blood goes in, urine goes out!

FILTRATION and

COLLECTION are the main functions of the kidney.

Also plays an important role in homeostasis through regulation of BP and acid-base balance.

Renal Pelvis

Major Calyx

Cortex

Interlobar Arteries & Veins

Bowman's Capsule

The Nephron

Distal Convoluted Tubule

Proximal Convoluted Tubule

The nephron is comprised of:

  • Glomerulus
  • Bowman’s capsule
  • Proximal convoluted tubule
  • Loop of Henle
  • Distal convoluted tubule
  • Collecting duct

TITLE

Loop of Henle

Collecting Duct

The Renal Corpuscle

Filtrate

Glomerular Capillaries

  • Made up of glomerulus, Bowman's Capsule, afferent/efferent arteriole
  • First step in filtration - composition similar to blood plasma
  • Efferent < Afferent arteriole to maintain pressure
  • Mesangial cells found within glomerulus - help regulate filtration
  • Juxtaglomerular and Macula Densa cells act on glomerulus to increase GFR

Glomerular

(Bowman's) Capsule

Efferent Arteriole

Afferent Arteriole

The Loop of Henle

Renal Cortex

Renal Medulla

Descending Limb

  • Only portion of nephron located in medulla.

  • Functions in the recovery of essential molecules (ie water, sodium)

  • Conserves energy and resources needed for survival by recycling essential molecules

Ascending Limb

Na+

Cl-

K+

H20

Collecting Duct

Multiple nephrons supply each collecting duct.

90-95% of solutes and water have been reabsorbed back into blood

Major roles of Collecting Duct:

1. PRINCIPAL cells

- water recovery ADH

- regulate osmolarity of blood and plasma

2. Aldosterone

- sodium recovery

- regulates Na+ recovery by reabsorption of Na+ and secretion K+ with Na+/K+ pump

3. INTERCALATED cells

- regulates pH levels by reabsorption of K+ and HCO3+ and secretion of H+.

Micturition

Ureter

Two Ureters

  • narrow tubes move urine from kidneys to bladder
  • back flow prevented with valves
  • when urine backed up or allowed to stand still = kidney infection
  • ureters empty urine into bladder every 10-15 seconds

Bladder

  • hollow organ, held by ligaments attached to organs and pelvic bones
  • walls relax and expand to store urine, contract and flatten to expel
  • typical adult bladder can store up to 475 ml for 2-5 hours

Two Sphincters

  • help keep urine from leaking, external = skeletal under voluntary control, the internal = smooth muscle, involuntary

Urethra

  • brings urine outside the body when brain signals bladder to tighten and signals sphincter to relax
  • when they happen in the right order, normal urination

Bladder

Urethra

When Things Go Wrong

Kidney Stones:

Increase of calcium, oxalate and uric acid within the urine

This imbalance can be attributed to:

  • Oxalate imbalance
  • One's diet e.g. chocolate, spinach
  • Uric acid imbalance
  • More susceptible if you are diabetic, overweight, or take diuretics
  • Calcium imbalance
  • Overstimulated parathyroid gland

Quiz Time!

Quiz Time!

Questions?

References

Betts, J. G., Desaix, P., Johnson, E., Johnson, J. E., Korol, O., Kruse, D., … Young, K. A. (2017). Anatomy & Physiology. OpenStax College. p. 1201-1236. Retrieved from https://d3bxy9euw4e147.cloudfront.net/oscms-prodcms/media/documents/AnatomyandPhysiology-OP_xxKIcSo.pdf

Huether, S. E., McCance, K. L., (2102) Understanding Pathophysiology, Fifth Edition. Elsevier Mosby. p 724-764. Retrieved from https://www.scribd.com/document/414429961/Understanding-Pathophysiology-Fifth-Edition-Sue-Huether-pdf

Khan Academy. Urinary System Introduction. (n.d.) Khan Academy. Retrieved April 9, 2020 form https://www.khanacademy.org/science/health-and-medicine/human-anatomy-and-physiology#introduction-to-the-kidneys

Lumen Learning. Anatomy and Physiology II. Lumen Learning. p.494-542. Retrieved from https://s3.amazonaws.com/lumenlearning/success/Master+PDFs/Anatomy-and-Physiology-II_9-22-17.pdf

Portis, A. J., & Sundaram, C. P. (2001, April 1). Diagnosis and Initial Management of Kidney Stones. Retrieved from https://www.aafp.org/afp/2001/0401/p1329.html

Tortora, G. J., & Derrickson, B. (2009). Principles of anatomy and physiology. Hoboken, NJ: Wiley

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