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Iron Oxide Nanoparticles Applications and Toxicity

JM

Jordan Miner

Transcript

Iron Oxide Nanoparticles: Applications and Toxicity

Kora Kukk, Jordan Miner, Natalie St. Louis

Important Micronutrient

Potential Drawbacks:

Coating Deterioration

Adverse Reactions to Coating

Cost

$$$

Engineers Involved and their Responsibilities

Antioxidant Defenses

Oxygen Transportation

  • Polyethylene Glycol (PEG)
  • Polyvinyl Alcohol (PVA)
  • Gelatin
  • Dextran
  • Pullulan

Bodily Functions

Biomedical and Chemical Engineers

  • Safety and SOP (MSDS)
  • Synthesizing the NPs
  • Knowing the interactions with the body

Oxidative Metabolism

Immune System Function

stable solution

unstable solution

DNA Homeostasis

Blood Production

Next Steps:

FDA premarket approval (PMA) for class III devices

But will it be safe?

$10-200 million

References:

Japans Applications

  • Focuses more on controlling NP size
  • Different synthesis techniques
  • Approval from different organizations
  • Different rules and regulations allow for faster approval
  • Malhotra, N., Lee, J., Liman, R., Ruallo, J., Villaflores, O., Ger, T., & Hsiao, C. (2020, July 10). Potential toxicity of iron oxide magnetic nanoparticles: A review. Retrieved February 26, 2021, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397295/#:~:text=The%20potential%20toxicity%20effects%20of,membranes%20on%20a%20cellular%20level.

  • Abakumov, M., Semkina, A., Skorikov, A., Vishnevskiy, D., Ivanova, A., Mironova, E., . . . Chekhonin, V. (2018, October 05). Toxicity of iron oxide nanoparticles: Size and coating effects. Retrieved February 26, 2021, from https://onlinelibrary.wiley.com/doi/abs/10.1002/jbt.22225#:~:text=On%20long%20exposure%20times%20(48,by%20using%20polyethylene%20glycol%20modification.

  • Ansari, M. O., Ahmad, M. F., Parveen, N., Ahmad, S., Jameel, S., & Shadab, G. G. (2017). Iron oxide nanoparticles-synthesis, Surface Modification, applications AND Toxicity: A review. Materials Focus, 6(3), 269-279. doi:10.1166/mat.2017.1410

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