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Sherylee Sanchez Santiago
November 4th, 2019
Pneumonitis
Chorioretinitis
Other Manifestations including:
Toxoplasma gondii (encephalitis)
Preferred regimen
Alternative regimens
(For those patients with seronegative antitoxo-igG)
Alternative:
Pyrimethamine- Bone Marrow Suppression, GI upset, headache, rash
Sulfadiazine- Crystalluria, rash, fever, leukopenia, N/V/D, hepatitis
Clindamycin- N/V, fever, rash, hepatotoxity, diarrhea (including C. difficile colitis
TMP/SMX- Rash (including SJS) fever, leukopenia, thrombocytopenia, azotemia, hepatitis, hyperkalemia, photosensitivity
Atovaquone- Headache, nausea, diarrhea, rash, fever, increase ALT/AST
Initiate:
Discontinue when:
Preferred:
Alternative:
1. Porter SB, Sande MA. Toxoplasmosis of the central nervous system in the acquired immunodeficiency syndrome. N Engl J Med 1992; 327:1643.
2. San-Andrés FJ, Rubio R, Castilla J, et al. Incidence of acquired immunodeficiency syndrome-associated opportunistic diseases and the effect of treatment on a cohort of 1115 patients infected with human immunodeficiency virus, 1989-1997. Clin Infect Dis 2003; 36:1177.
3. Renold C, Sugar A, Chave JP, et al. Toxoplasma encephalitis in patients with the acquired immunodeficiency syndrome. Medicine (Baltimore) 1992; 71:224.
4. Luft BJ, Remington JS. Toxoplasmic encephalitis in AIDS. Clin Infect Dis 1992; 15:211.
5. Grant IH, Gold JW, Rosenblum M, et al. Toxoplasma gondii serology in HIV-infected patients: the development of central nervous system toxoplasmosis in AIDS. AIDS 1990; 4:519.
6. Blaser MJ, Cohn DL. Opportunistic infections in patients with AIDS: clues to the epidemiology of AIDS and the relative virulence of pathogens. Rev Infect Dis 1986; 8:21.
7. Leport C, Chêne G, Morlat P, et al. Pyrimethamine for primary prophylaxis of toxoplasmic encephalitis in patients with human immunodeficiency virus infection: a double-blind, randomized trial. ANRS 005-ACTG 154 Group Members. Agence Nationale de Recherche sur le SIDA. AIDS Clinical Trial Group. J Infect Dis 1996; 173:91.
Toxoplasmosis