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SUDDEN BEHAVIOURAL CHANGE & MOOD DISORDERS

LEARNING OUTCOMES

  • Ability to safely approach a patient with aggressive behaviour
  • Recognition of the causes contributing to sudden behavioural change
  • Non-pharmacological measures in management of delirium
  • Proper diagnosis of affective disorders

Night gathers,

and now my watch begins

You are MO2 Oncall and ED rang you to refer a 44Y homeless man for:-

i) hyperglycemia (Dstix 20.3, urine glucose +++ ketone –ve)

ii) AKI 2” dehydration (Cr 124 baseline 64, Na 126, K 3.3)

ED senior remarked that he is escorted by police for disrupting the peace by damaging public property. Not much is known about the patient except his forensic records revealed that he underwent:-

- community service for juvenile theft in his mid teens

- troubled past with polysubstance use

- convicted of assault and imprisoned from 2007-2013

- voluntarily admitted under Pusat Al-Islah from 2013-2015

No records exist from 2015 onwards.

!

However police interviewed some eyewitnesses familiar with him who often spotted him working in the nasi katok stall at Serusop for the past 7 years. He would sleep below the stairs on the shoplots in the night. Sometimes he would be spotted screaming and kicking door entrances. His employer could not be reached at present.

Once arriving at trolley area, ED senior exercised caution as he sedated pt with IM midazolam 5mg 40 min ago due to aggressive behaviour.

Upon entering Room 2, you find 2 police officers and the patient on the stretcher with one arm and foot handcuffed to the frame. He is semi-conscious, barely opening eyes to voice and mumbling. You ask him for his name but he is neither oriented in time, place or person.

You attempt to get some collateral from police officers however they know little and are only present until pt is admitted to the ward. As you proceed to perform physical exam on the pt, he starts to exhibit signs of aggression by unshackling himself from the handcuffs while grunting.

TAMING THE BEAST

Which of the following measures is appropriate given the current situation?

A: Give oral sedation e.g. PO lorazepam 2mg STAT

B: Give IM sedation e.g. IM haloperidol 5mg STAT

C: Instruct police officers to remove handcuffs

D: Correct hyperglycemia (basal-bolus insulin) and electrolyte derangement (IV fluids)

E: Verbal de-escalation and ensure safe surroundings

Verbal de-escalation

After successfully persuading the patient to take oral sedation, you perform a quick neurological exam before he dozes off. Able to follow most instructions and neurologically intact except for reduced sensation & proprioception all limbs. You noticed bruises and superficial ulceration on his MCP joints as well as an infected Rt toe with poorly healed foot ulcers. Apart from reduced JVP and dry mucous membranes, rest of examination is unremarkable and you note your findings.

Post-take

During PTWR, you present your case to the medical consultant oncall and treating the patient as hyperglycemia not in crisis on BG of poorly-controlled T2DM, AKI 2” dehydration and infected diabetic foot ulcers. Your consultant agrees with your assessment and decides for admission under AMU with Psych & Ortho input. In addition, your consultant asked the following:-

Based on the information given to you so far, what is the most likely reason for his aggressive behaviour?

A: Schizophrenia

B: Bipolar affective disorder, manic episode

C: Metabolic disorder

D: Neurological disorder

E: Substance use disorder

FOULD'S HIERARCHY

THE CALM....

The patient is then stabilised at AMU for the next three days however he appears to communicate with one or his favourite two word sentences “inda tau”. At times, he would not respond and mutters as his eye contact wanders around. In the meantime, Psychiatry hasn’t had any luck contacting the employer (notes mentioned that the nasi katok stall doesn’t have a valid permit) and MSW is in touch with JAPEM for any relative contact details or patient’s files. Ortho has ordered a pus swab CS, performed debridement of infected toe and started IV co-amoxiclav.

...BEFORE THE STORM

On D4 admission, AMU nurse contacts you to say that patient is pyrexial at 40.2degC, agitated and screaming “gangguan” (disturbances). On bedside review, pt is pointing towards the IV drip and repeated the words “gangguan” with the nurse preventing him from pulling out his drip. You address his name but he only looks at you briefly before becoming fixated with the IV drip.

Which of the following is the least appropriate intervention for this scenario?

A: Address cognitive impairment and/or disorientation

B: Address potential sources of infection

C: Address disturbed behaviour with sedation

D: Address pain

E: Promote good sleep patterns

Causes of sudden behavioural change/acute behavioural disturbance

Neurological disorders

  • Alzheimer’s disease
  • Brain infection
  • Tumours
  • Head injuries
  • MS
  • PD
  • Seizure disorders
  • Stroke

Drugs

  • Intoxication: Alcohol, Stimulants (cocaine, methamphetamine), Hallucinogen (PCP, LSD, bath salts)
  • Withdrawal
  • Side effects: drugs affecting brain function (AED, antidepressant, antipsychotic, sedative, stimulant), anticholinergic drugs (antihistamine), opioid, corticosteroids

Systemic disorders

  • Acute organ failure (liver & kidney)
  • Hypoglycemia
  • SLE
  • Thyroid disorder

ESCALATING TENSIONS

You move patient to one of the AMU rooms and initiate delirium management protocol.

You identify the source of the infection to come from the Rt foot however there appear to be multiple small abscesses below the knee.

You captured an image and WhatsApped to your SMO who recommended escalating Abx to IV meropenem, repeat set of investigations including FBC, CRP, UEC, LFT, blood CS & CXR.

Patient’s condition deteriorated slightly on the next 30-minute review and following discussion with your senior you are asked to refer to ICU for supportive therapy and notify the ID team.

Within an hour later, lab phoned the nursing staff informing that the pus swab grew Burkholderia pseudomanii.

STEPPING DOWN

You have since rotated into ID and have taken up the case of the homeless man now lodged in ICU for meiloidosis with multi organ involvement. Although pt did not require intubation, he required plenty of supportive therapy and deconditioned throughout his long stay in ICU. He was stepped down after 1 month and placed in the general ward where he underwent rehab by OT/PT. Initially he communicates in short sentences, tolerates oral feeds and participates in rehab.

Gradually over the next few weeks nursing staff & OT/PT reports that pt is becoming increasingly withdrawn, eventually refusing to partake in rehab, reduced oral intake to 2-3 tablespoons, insomnia and was heard remarking “baiktah ku mati”

DEPRESSION CRITERIA

Based on your assessment, what severity of depression does this pt have?

Core: low mood, anergia, anhedonia

Mild: 2 core + 2 sx

Mod: 2 core + 3-4 sx

Severe: 3 core + >5sx

S leep changes

I nterest loss

G uilt

E nergy loss

C oncentration loss

A ppetite changes

P sychomotor changes

S uicidality/self harm

Duration: >2 weeks

ADJUSTMENT DISORDER & BEREAVEMENT

You inform your consultant during the next WR who agreed with your assessment and started on antidepressant fluoxetine 20mg OD. In the following week, he started to complain of abdo cramps, nausea and loose stools. Gradually he started to participate in rehab and regained some of his appetite back. However the OT/PT remarked that pt has been rather flirtatious and talkative towards them in addition to being easily distracted which hinders rehab. He is also mildly irritable when asked to take his oral medications and disturbs other patients in the night. Despite that, nursing staff are able to manage him albeit barely.

What is the most appropriate pharmacotherapeutic course of action?

A: Switch to another antidepressant

B: Stop antidepressant

C: Add mood stabilizer

D: Add antipsychotic

E: Add antispasmodic

BIPOLAR CRITERIA

D istractibility

I ndiscretion

G randiosity

F light of ideas

A ctivity increase

S leep decrease

T alkativeness

At least 1 manic/hypomanic episode + 1 depressive episode

Duration: Hypomanic >4d Manic >1wk

Based on your assessment, is this BPAD I or BPAD II?

The Mood Spectrum

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