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Linear IgA Bullous Dermatosis
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Linear IgA Bullous Dermatosis
GABRIELLA ANDRADE
TECHNICAL ENGLISH
DR. JOHN MOSCOSO
INTRODUCTION
DEFINITION
Linear IgA bullous disease is an autoimmune bullous disease in which blisters form on the skin and mucous membranes. This is a provocative case of characteristic findings on direct immunofluorescence from a skin biopsy, in which an IgA antibody line can be found just below the epidermis.
APPLICATIONS IN NURSING
APPLICATIONS IN NURSING
Linear IgA bullous disease usually arises spontaneously, but can be triggered by an infection or medication.
Most patients with linear IgA bullous dermatosis improve or disappear with dapsone 50–100 mg daily.
PROS AND CONS
The mucous membranes are affected in almost 90% of cases. Painful erosions appear because the blisters break, the most affected are the oral, nasal and conjunctiva, which can cause scarring and synechiae, and when they concern the cornea they can cause decreased visual acuity, and even blindness. You can take other mucosa, but less frequently, such as pharynx, larynx, rectum and esophagus.
PROS AND CONS
ISSUE APPLIED TO ECUADOR
ISSUE APPLIED
IN ECUADOR
A 72-year-old man developed tense blisters that affected 60% to 70% of his body surface, including the torso (lower abdomen and back) and extremities. The biopsy showed subepidermal bullous dermatosis with neutrophils and eosinophils, consistent with idiopathic immunoglobulin A (IgA) idiopathic bullous dermatosis.
CONCLUSION
Linear IgA bullous disease affects adults of all ages, but is more common in old age, while childhood IgA dermatosis is a disease of very low incidence in the international scientific community.