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The hormone involved in Addison's disease is cortisol. Cortisol Is produced in the adrenal glands. The targeted organs and structures for cortisol are the liver, muscles, adipose tissue and the pancreas.
The secretion of cortisol is regulated by hypothalamus hormone (CRH) and the pituitary hormone (ATCH) located in the hypothalamus-pituitary-adrenal axis.
Cortisol controls blood sugar levels, regulates metabolism, helps to reduce inflammation, and assists with memory formulation
Cortisol is involved in various maintenance such as blood pressure, the immune system, anti-inflammatory actions and the metabolism of proteins, carbohydrates and adipose.
Addison's disease is the hypo-secretion of cortisol and mineralocorticoids, meaning the body does not produce enough of them.
Hypo-secretion can cause weakness, fatigue, and low blood pressure. When Addison's disease is left untreated of you have a damaged adrenal gland symptoms can include sudden dizziness, vomiting and even loss of consciousness.
Hormone replacement therapy is used to correct levels of steroid hormones that aren't being produced. Oral medications include: Hydrocotisone (Cortef), predinsone or methylprednisolone to replace cortisol.
Addison's disease has been linked to cause emotional and behavioral changes. This disorder has been associated with irritability, depression and poor concentration.