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Immunosuppression after Renal Transplant Failure.

David Gomez

August 2022

Immunossupresion withdrawl after Tx Failure= HLA sensitization

HLA sensitization = less Re-Tx Potencial

No Guidelines on what to do after Tx Failure

Main Ideas

15% Kidney Tx, lost in the first 5 years

20% Re-Tx

Re-Tx = Reduce Mortality by 45%

quick Data

HLA main Factor for Renal-Tx.

Main HLA influence

Tx in the past, Pregnacies, Blood Trasnfusions.

short info in Renal-Tx

158 Patients

only 77 Patients (Tx Failure 1st and 2nd Tx)

Our Study:

What to do after Tx-Failure

Results

Median Duration of Tx: 10 years.

No CNI(Tacrolimus) + Graft Nephrectomy = Increase of dnDSA 90%

CNI Mainteance = Lower HLA sensitization (by 4x more with IS (Corticoids))

Tacrolimus serum contetracion

3ng/ml = lower dnDSA

Graft nephrectomy = HLA sensitization.

We DID NOT measure CNI levels, in all the patients, we cannot establish a fix dosis to prevent HLA sensitization

limitation

conclusion

& discussion

conclusion

&

discussion

conclusion

Graft Lost is High, mortality after Tx-failure is high.

Graft nephrectomy = Higher HLA sensitization

CNI(Tacrolimus) maintenance after Tx-failure = Reduced HLA sensitization (x4 compared to no IS or Corticoids(prednisolon))

We recommend to maintain IS with Tacrolimus after Graft Failure. To improved the possiblity of Re-Tx, especially when we anticipate a short-medium term Re-Tx

Publication

https://pubmed.ncbi.nlm.nih.gov/32231087/

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