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Safety and efficacy of bempedoic acid to reduce LDL cholesterol
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SAFETY AND EFFICACY OF BEMPEDOIC ACID TO REDUCE LDL CHOLESTEROL
DEFINITION
LDL CHOLESTEROL
Low density lipoproteins (LDL) contain a higher proportion of cholesterol and protein and are considered "bad" cholesterol. It is bad because it becomes part of the plaque, which can clog arteries and make heart attacks and strokes more likely.
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APLICATION IN MEDICINE
APLICATION IN MEDICINE
Inability to tolerate statins because of muscle symptoms contributes to uncontrolled cholesterol levels and insufficient cardiovascular risk reduction. Bempedoic acid, a prodrug that is activated by a hepatic enzyme not present in skeletal muscle, inhibits ATP‐citrate lyase, an enzyme upstream of β‐hydroxy β‐methylglutaryl‐coenzyme A reductase in the cholesterol biosynthesis pathway.
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PROS AND CROS
PROS AND CONS
- Reduces the levels of low density lipoprotein (LDL) cholesterol
- Data are limited regarding the safety and efficacy of treatment in long-term studies with patients with hypercholesterolemia
ISSUE APPLIED IN ECUADOR
The trial involved 2230 patients, of whom 1488 were assigned to receive bempedoic acid and 742 to receive placebo. The mean LDL cholesterol level (± SD) at the beginning of the study was 103.2 ± 29.4 mg per deciliter.
CONCLUSION
Bempedoic acid added to maximally tolerated statin therapy did not lead to a higher incidence of overall adverse events than placebo and led to significantly lower LDL cholesterol levels.