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Nintedanib in Progressive Fibrosing Interstitial Lung Diseases

José Andrés Jara Escobar

Definitions

  • Nintedanib is an intracellular inhibitor of tyrosine kinases, it inhibits processes involved in the progression of lung fibrosis.

  • Pulmonary fibrosis is a chronic and progressive lung disease where the air sacs in the lungs, called the alveoli, become scarred and stiff, making it difficult to breathe and get enough oxygen into the bloodstream.

Applications in Medicine

Its important to know about the symptoms, signs and the new treatments for this disease.

In case of nintedanib the efficacy of this drug has been shown in idiopathic pulmonary fibrosis

Applications in Medicine

Pros and Cons

Pros:

  • In the overall population, the adjusted rate of decline in the FVC was −80.8 ml per year with nintedanib and −187.8 ml per year with placebo, for a between-group difference of 107.0 ml per year

Cons:

  • Although the efficacy of nintedanib has been shown in idiopathic pulmonary fibrosis, its efficacy across a broad range of fibrosing lung diseases is unknown.

Pros and Cons

Issue Applied in Ecuador

In Ecuador its important to know about this disease, how to diagnose it and what are the multiple treatments for this disease

Issue applied in Ecuador

Conclusion

In patients with progressive fibrosing interstitial lung diseases, the annual rate of decline in the FVC was significantly lower among patients who received nintedanib than among those who received placebo. Diarrhea was a common adverse event.

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