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EVOLUION OF ANTIGEN RECEPTORS
EVOLUTION OF ANTIGEN RECEPTORS
ELIFNAZ EKER
MIDDLE EAST TECHNICAL UNIVERSITY
OUTLINE
IMMUNE SYSTEM
- Antibody and antigens
- Antigen receptors
- ...
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ANTIGEN
Antigen & Antibody
Antigen : foreign substance that initiates the immune response.
Antibody generator
Ex. viruses, bacteria, chemicals or pollens
ANTIBODY
Antibody (Immunoglobin)
1 antibody = 2 heavy chains + 2 light chains
1 antibody = 2 antigen binding regions
constant region: common for all antibodies
Hyper-variable region ~ V region : region that light and heavy chain coming together. Creates diversity in antibody
- produced by white blood cells
- specialized Y-shape proteins
- match antigen (lock-key)
ADAPTIVE IMMUNE SYSTEM
Adaptive Immune System (B and T Lymphocytes)
BCR
& TCR
Adaptive Immune System (B and T Lymphocytes)
90% of them have similar structure, the rest part creates specificity.
GOAL
SOURCE OF DIVERSITY
KPI
KPI
18,5 %
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+ 13,5 M
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TARGET MARKET
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TARGET MARKET
STRATEGY
#4
#3
#2
STRATEGY
#1
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TIMELINE
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FOCUS TOPICS
FOCUS TOPICS
#2
#1
#3
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