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Cell Signaling Diseases Summative AP Bio Project: Alopecia
3
Transcript
Cell Communication in Alopecia
ABOUT
An autoimmune disease that causes hair loss on the scalp and other parts of the body
Alopecia
Common; usually develops during childhood
Regrowth is unpredictable but differs based on that person with alopecia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129127/
Links
https://www.naaf.org/alopecia-areata
Reception: target cell detects signal molecue outside cell
Transduction: signal molecule, ligand, binds to receptor and causes a change; secondary messegnger, cAMP or calcium, activates protein kinases, which then cause phosphorylation
NORMAL SIGNAL TRANSDUCTION PATHWAY
Response: specific cellular action caused signal protein kinases cause phosphorylation
Visual
FAULTED SIGNAL TRANSDUCTION PATHWAY
Target cell fails to detect signal molecule/mistakes signal molecules as a threat
Reception
Lymphocytes (white blood cells) invade receptors around hair follicles
Lymphocytes (white blood cells) invade receptors around hair follicles
Transduction
The normal/regular ligands are not able to bind to the receptors anymore (because of the invasion)
The normal/regular ligands are not able to bind to the receptors anymore (because of the invasion)
Response
Secondary messengers and phosphorylation are "canceled out," cutting off the cascade and preventing hair growth
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