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as coronary death, myocardial infarction, coronary insufficiency, angina, cerebrovascular accidents, revascularisation, peripheral artery disease, and heart failure.
F-FDG (Fluorodeoxyglucose) was given intravenously after an overnight fast -> PET/CT
Image analyses (appendix) were done by a radiologist (AI) who was blinded to the clinical data and used a dedicated workstation.
2 imaging studies
Hypothesis:
Perceived stress is associated with resting amygdalar metabolic activity, arterial inflammation, and inflammatory biomarkers.
Cross-sectional
psychometric measures of perceived stress, resting amygdalar metabolic activity, and atherosclerotic inflammation.
N = 13
Longitudinal
resting amygdalar metabolic activity, atherosclerotic inflammation, and subsequent cardiovascular events
N = 293
Stress prompts activation of
1. the sympathetic nervous system
2. hypothalamic–pituitary– adrenal axis, leading to increases in circulating
catecholamines, glucocorticoids, and (eventually) inflammatory cytokines.
3. + stress can increase heart rate and blood pressure via the autonomic nervous system, all of
Anna Dudka,
Goethe University Frankfurt, WiSe 23/24, 25.01
Tawakol, A., Ishai, A., Takx, R. A., Figueroa, A. L., Ali, A., Kaiser, Y., ... & Pitman, R. K. (2017). Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study. The Lancet, 389(10071), 834-845.