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Recent Advances in Applications of Sorted Single-Walled Carbon Nanotubes
6
Ultra-Low Doses of Chirality Sorted (6,5)
Carbon Nanotubes for Simultaneous
Tumor Imaging and Photothermal Therapy
Ultra-Low Doses of Chirality Sorted (6,5) Carbon Nanotubes for Simultaneous
Tumor Imaging and Photothermal Therapy
About
©Bati,et.al. "Recent Advances in Applications of sorted single-walled carbon Nanotubes"
.Advanced Functional Materials (2019) 29, 1902273
©Antaris,et.al. "Ultra-Low Doses of Chirality Sorted(6,5) Carbon Nanotubes forSimultaneous Tumor Imaging and Photothermal Therapy".ACS Nano Organisation (2013) VOL. 7 ’ NO. 4 ’ 3644–3652
Authors of the review article:
Recent Advances in Applications of Sorted Single-Walled Carbon Nanotubes
1
Abdulaziz S. R. Bati
A. S. R. Bati, Dr. M. Batmunkh, Prof. J. G. Shapter
Australian Institute for Bioengineering and Nanotechnology
The University of Queensland
St. Lucia, Brisbane, Queensland 4072, Australia
E-mail: j.shapter@uq.edu.au
2
Munkhbayar Batmunkh
Dr. L. Yu, Dr. M. Batmunkh
College of Science and Engineering
Flinders University
Bedford Park, Adelaide, South Australia 5042, Australia
Authors
3
Joseph G. Shapter
Prof. J. G. Shapter
College of Science and Engineering
Flinders University
Bedford Park, Adelaide, South Australia 5042, Australia
Authors of the original paper
Ultra-Low Doses of Chirality Sorted (6,5) Carbon Nanotubes for Simultaneous Tumor Imaging and Photothermal Therapy
Omar K. Yaghi
Alexander L. Antaris
Joshua T. Robinson
Department of Material Science and Engineering, Stanford University, Stanford, California 94305, United States
Department of Chemistry, Stanford University,
Stanford, California 94305, United States
Authors of the original paper
Guosong Hong
Hongjie Dai
Shuo Diao
Richard Long
Department of Chemistry, Stanford University,
Stanford, California 94305, United States
Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305,
United States
Presented by:
1
Inara Bakhsh
ebaksh@stu.edu.sa
2
Bayan Ibrahim
Bay1418@hotmail.com
3
Ohood Al-Matiri
Ohood.a.1419@gmail.com
Presenters
4
Zaineb Al-Samadani
zalsamdani0001@stu.kau.edu.sa
5
Raghad Zamzami
Raghod_hz@hotmail.com
Supervised by: prof. Soha M. Al-bukhari
Introduction
Intro
SWCNTs has been discovered in 1992 it got an enormous attention in several fields due to its unique electrical, thermal, optical and biological Properties
we can use it in many applications such as sensors, batteries aswell as biological/biomedical fields.
How Does it look like ?
SWCNTs is a 1D hollow cylindrical tube formed by rolling up a single graphene sheet depends on the properties of wrapping direction, dimensions and orientation properties.
showing how SWCNTs are ideal for vivo imaging and photothermal therapy
Objectives
the use of highly purified Nanotubes for a diverse range of potential applications
Main focus
Purpose and
Summary of the study
to summarize and critically discuss applying this material
why are they are promising for nanomedicine.
Review of Literature
- A. E. Islam, J. A. Rogers, Cloning by SWCNT
Review of Literature
- Liu, Haitao. and his Co-workers. post-purification techniques in chromatography
- Angela R. Hight Walker. and her Co-workers. Extraction
Problem/Hypothesis
Problem/Hypothesis
There has been many Concerns reviewed by several publishers,
Which is the Separation/Growth Control of SWCNTs. but our main Problem has not been reported yet which is the use of highly purified nanotubes for a wide range of applications.
Therefore, we hypothesis and focus on investigating the
effect of the separated pure nanotubes in a highly controllable
manner in various advanced device applications, also the utilization
of separated SWCNTs in these field and how of a great impact it makes in biomedical field.
Tumor Imaging
Methodology
(SWCNTs) have unique properties make them promising theranostic agents capable of tumor imaging which is :
1-capable of high-resolution in vivo imaging
and deep tissue NIR .
unique properties
How Does it work ?
SWCNTs implanted in tumor tissue and then Monitoring the injected dose through near-infrared (NIR) fluorescence imaging over a long
period of time (up to 56 days).
How Does it work ?
nanotubes have all allowed the efficient
vascular imaging of mice
The NIR-I fluorescence of SWCNTs has
been used to probe cancer tissue.
How is this happening?
2-physical state describing tortuous tumor
vasculature which increases tumor uptake
of intravenously injected nanomaterials
compared to healthy tissue.
more unique properties
Some advantages
1-In the implanted of there’s no nanotubes were observed in other organs, suggesting that they remained at the implanted area and did not diffuse into other sites.
advantages
2- toxicity of CNTs is a potential limitation for
this purpose
Applications of Sorted Carbon Nanotubes:
Data/Discussion
This section outlines the advancements of separated nanotubes in various fields of science and technology.
biological/medical fields
Separation and Surfactant Exchange HiPCO SWCNTs:
a mixture of many chiralities with 16 diameters in a range of 0.71.1 nm.
- the first separation at the bottom of a second, linear density
- This second separation, known to concentrate semiconducting SWCNTs at low buoyant densities, ultimately boosted.
- The bile salt sodium cholate can solubilize SWCNTsin water; however, cholate dispersed SWCNTs aggre-gate when excess sodium cholate is removed from the solution
Isolationof(6,5)SWCNTsemployingdensitygradientultracentrifugation(DGU).(aandc)Photographsofcentrifuge tubes following DGU after the first iteration in a nonlinear density gradient (a) and after the second iteration in a linear gradient (c). (b and d) Normalized absorbance spectra comparing (b) first iteration (6,5) to bulk HiPCO and the (d) pink (6,5) band to the yellow band at a higher buoyant density slightly enriched in metallic SWCNTs. (e) Photoluminescence spectra of (6,5) compared to as-synthesized HiPCO. (f) The absorbance spectra (1 mm path length) of the mass balanced (6,5) and HiPCO preceding intravenous injection
Discussion
- While very small quantities of SWCNTs are capable of producing a large number of electronic device
more of biological/medical fields
- Signs of promise for isolating suffcient amounts of near-single chirality SWCNT populations for in vivo use
(fig1.a)
- DGU separations allowed for the collection of a suffcient quantity of (6,5) SWCNTs to treat tumors. (fig1.a)
- This is the first in vivo application of near single-chirality SWCNTs for effective tumor photoablation
Why is this Happening?
- Biocompatible carbon-based nanomaterials, due to high NIR light absorption ,have increasingly been used as photosensitizing agents for in vivo photothermal therapy. (fig1.f)
- work is on going to investigate the long-term biodistribution/ retention of SWCNTs and their chirality dependence.
(fig1.f)
The absorbance spectra (1mmpath length) of the mass balanced (6,5) and HiPCO
preceding intravenous injection.
Conclusion/ Perspectives :
Conclusion
Our Hypothesis was correct SWCNTS
1- materials with a broad range of potential applications .
2- progress has been achieved in the preparation of highly enriched nanotube samples.
3- the utilization of these materials Especially in the optical and biomedical properties.
4-further advancements in this Field is needed.
How to improve SWCNTs
Improving
SWCNTs
1- the search for a simple and rapid sorting alternative methods with inexpensive equipment and
chemicals are necessary.
2-facile, low cost, scalable and controllable routes for pure single electrical type/chirality enrichment nanotubes need to be developed.
How to improve SWCNTs
More ways to Improve
SWCNTs
SWCNT applications will be progressing rapidly in the future and open the doors to many more potential applications in this promising and bright field.
References:
[1] S. Iijima, T. Ichihashi, Nature 1993, 363, 603.
[2] D. Bethune, C. H. Kiang, M. De Vries, G. Gorman, R. Savoy,
J. Vazquez, R. Beyers, Nature 1993, 363, 605.
[3] W. Zhou, X. Bai, E. Wang, S. Xie, Adv. Mater. 2009, 21, 4565.
[4] S. Nanot, E. H. Hároz, J. H. Kim, R. H. Hauge, J. Kono, Adv. Mater.
2012, 24, 4977.
References
[15] T.Yamada,Y.Hayamizu,Y.Yamamoto,Y.Yomogida,A. Izadi-Najafabadi, D. N. Futaba, K. Hata, Nat. Nanotechnol.2011, 6, 296.
[18] B. J. Landi, M. J. Ganter, C. D. Cress, R. A. DiLeo, R. P. Raffaelle,
Energy Environ. Sci. 2009, 2, 638.
[19] R. Seidel, A. P. Graham, E. Unger, G. S. Duesberg, M. Liebau,
W. Steinhoegl, F. Kreupl, W. Hoenlein, W. Pompe, Nano Lett. 2004,4, 831.
[20] A. E. Islam, J. A. Rogers, M. A. Alam, Adv. Mater. 2015, 27, 7908.
[30] J. Liu, C. Wang, X. Tu, B. Liu, L. Chen, M. Zheng, C. Zhou, Nat.
Commun. 2012, 3, 1199.
[31] Y. Yao, C. Feng, J. Zhang, Z. Liu, Nano Lett. 2009, 9, 1673.
[32] Y. Wang, M. J. Kim, H. Shan, C. Kittrell, H. Fan, L. M. Ericson,
W.-F. Hwang, S. Arepalli, R. H. Hauge, R. E. Smalley, Nano Lett.
2005, 5, 997.
[341] B. L. Allen, P. D. Kichambare, A. Star, Adv. Mater. 2007, 19, 1439.
[342] B. S. Wong, S. L. Yoong, A. Jagusiak, T. Panczyk, H. K. Ho,
W. H. Ang, G. Pastorin, Adv. Drug Delivery Rev. 2013, 65, 1964.
[343] H. Gong, R. Peng, Z. Liu, Adv. Drug Delivery Rev. 2013, 65, 1951.
[356] S. Diao, J. L. Blackburn, G. Hong, A. L. Antaris, J. Chang, J. Z. Wu,
B. Zhang, K. Cheng, C. J. Kuo, H. Dai, Angew. Chem. 2015, 127,14971.
[357] J. Yang, Q. Zhao, M. Lyu, Z. Zhang, X. Wang, M. Wang, Z. Gao,
Y. Li, Small 2016, 12, 3164.
16. Green, A. A.; Hersam, M. C. Nearly Single-Chirality SingleWalled Carbon Nanotubes Produced via Orthogonal Iterative Density Gradient Ultracentrifugation. Adv. Mater. 2011, 23, 2185–2190.
34. Ghosh, S.; Bachilo, S. M.; Weisman, R. B. Advanced Sorting ofSingle-Walled CarbonNanotubesbyNonlinearDensityGradient Ultracentrifugation. Nat. Nanotechnol. 2010, 5, 443–450.
17. Ha, M. J.; Xia, Y.; Green, A. A.; Zhang, W.; Renn, M. J.; Kim,
C. H.; Hersam, M. C.; Frisbie, C. D. Printed, Sub-3V Digital
Circuits on Plastic from Aqueous Carbon Nanotube Inks.
ACS Nano 2010, 4, 4388–4395.
More
References
18. Chen, P. C.; Fu, Y.; Aminirad, R.; Wang, C.; Zhang, J. L.; Wang,
K.; Galatsis, K.; Zhou, C. W. Fully Printed Separated Carbon
Nanotube Thin Film Transistor Circuits and Its Application
in Organic Light Emitting Diode Control. Nano Lett. 2011,
11, 5301–5308.
19. Tyler, T. P.; Brock, R. E.; Karmel, H. J.; Marks, T. J.; Hersam,
M. C. Electronically Monodisperse Single-Walled Carbon
Nanotube Thin Films as Transparent Conducting Anodes
in Organic Photovoltaic Devices. Adv. Energy Mater. 2011,
1, 785–791.
20. Javey, A.; Guo, J.; Wang, Q.; Lundstrom, M.; Dai, H. J. Ballistic
Carbon Nanotube Field-Effect Transistors. Nature 2003,424, 654–657.
38. Wenseleers,W.;Vlasov,I.I.;Goovaerts,E.;Obraztsova,E.D.; Lobach,A.S.;Bouwen,A.EfficientIsolationandSolubilization of Pristine Single-Walled Nanotubes in Bile Salt Micelles. Adv. Funct. Mater. 2004, 14, 1105–1112.
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