Presentation1

Complexometric Determination of Total Aluminum and Magnesium of Drug Tablets (Antacids)

CONCLUSION

PREPARED BY:

Based on gathered data and analytical calculations,

Gel-malicid < Maalox Plus < Kremil-S < Maalox No.1

Saramae Feliciano

Angelica Mae Gallego

Ian Rannie Garcia

Zen Tolentino

Errors arosed, but fortunately researchers were able to come with a reasonable datum to compare the different commercial tablets

Antacids may contain different active ingredients such as, calcium carbonate, magnesium hydroxide, aluminum hydroxide, and sodium, either alone or in various combinations

Antacids containing magnesium hydroxide and sodium carbonate dissolves rapidly in the stomach, bringing faster relief

Meanwhile, antacids containing aluminum hydroxide and calcium dissolves slower and may take time to begin working. However, the longer an antacid stays in the stomach, the longer it works.

INTRODUCTION

Excessive acid production can cause stomach problems in the body, to cure such disease, antacids are ingested to help neutralize the stomach and thus, alleviate the pain

MECHANISM OF ACTION:

Antacids either directly neutralize acidity, increasing the pH, or reversibly reduce or block the secretion of acid by gastric cells to reduce acidity in the stomach. When gastric hydrochloric acid reaches the nerves in the gastrointestinal mucosa, they signal pain to the central nervous system.

OBJECTIVES

• To apply wide knowledge about titrimetric methods.
• To apply different techniques involved in complexometric methods of determination of metal
• Also, to apply techniques in preparing buffer solutions
• Lastly, provide detailed analysis on the total aluminum and magnesium content of different commercial antacid tablets.

METHODOLOGY

The samples analyzed in this experiment are from commercially available tablets, containing aluminum hydroxide and magnesium hydroxide as their active ingredients.

Complexometric titration with EDTA and its back-titration with standardized zinc sulfide using Eriochrome black T as the indicator in the appropriate buffer solution was done for the analysis of the antacid tablets

Analysis of Tablets

RESULTS & DISCUSSION

Back- titrated with zinc sulfide solution to the endpoint

Filtered in 250 volumetric flask and diluted to mark

weighed 0.7 g of tablet

STANDARDIZATION OF EDTA

Dissolved in dilute HCl and distilled water; heated for 20 mins.

10.00 mL aliquot of sample solution, added with 20 mL bicarbonate-carbonate buffer solution, 30 mL excess EDTA; heated for 5 mins. ; 3 drops of Eriochrome black T

(cc) image by nuonsolarteam on Flickr

Titrated with EDTA to endpoint

10.00 mL aliquot of Zinc solution

DATA

Commercial Antacid Tablets:

Kremil-S (Therapharma B.I.V. Limited)

Gel-malicid (Am-Europharma)

Maalox Plus (Sanofi-aventis)

Maalox No.1 (Sanofi-aventis)

Weighed 1.861 g EDTA & 1.438 Zinc sulfate

Added 3 drops of Eriochrome Black T

Dissolved in 500 mL volumetric flask

TO SOLVE FOR THE MILLIMOLES OF EACH TABLET

DISCUSSION

Maalox No.1 tablet clearly showed the highest number of calculated millimole

Kremil-S showed the highest number of claimed millimole

TO SOLVE FOR THE MOLARITY OF EDTA

ERRORS

Difficulty in confirming if the titration end point has been reached

Error in the preparation of sample solution - under weighed or over dilution.

Fluctuating pH level of buffer solution