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Evan Syndrome
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Evans Syndrome
Basis of Evan Syndrome
ES is an autoimmune disease. The body's immune system produces antibodies that destroy red blood cells, platelets, and sometimes white blood cells.
Evans Syndrome (ES) can affect unborn babies, children, grown adults, dogs, cats, and other animals.
There is no known genetic cause of ES and is a rare occurrence in family lines. There has also been no recorded happenings of Evans Syndrome contagion
ES is potentially life-threatening if not cared for properly.
Treatment for ES can include:
- immunosuppressive drugs
- removal of spleen
- stem cell transplants
Ethical Issues
Stem cell transplants are used as a last resort when treating Evans Syndrome. This is mainly because of the mixed results it has produced.
Stem Cell Therapy
Autologous Stem Cell Transplantation
Multipotent stem cells are taken from the patient's bone marrow before treatment. After the treatment, the stem cells are re-infused in the bone marrow after the disorder progresses.
Stem cell transplant results, particularly allogeneic stem cell transplants, have been generally 50/50. More research needs to be done to discover their potential effectiveness on Evans Syndrome
Allogeneic Stem Cell Transplantation
Multipotent stem cells are extracted from a close relative's bone marrow of the patient. Those stem cells are then inserted in the patient's bone marrow.
Sources:
- https://rarediseases.org/rare-diseases/evans-syndrome/
- http://emedicine.medscape.com/article/955266-treatment
Symptoms
Low Levels of White Blood Cells
More common than the other two, people with neutropenia caused by Evans Syndrome may get fevers, ulcers on the mucous membranes of the mouth, and a general feeling of poor health.
Low Levels of Platelets
People with thrombocytopenia caused by Evans Syndrome may get red or purple spots on their skin, a rash consisting of purple spots, and can be more susceptible to bruising
Low Levels of Red Blood Cells
People with anemia caused by Evans Syndrome may experience fatigue, pale skin colouring, dark coloured urine, lightheadedness, and a rapid heartbeat.