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Transcript

What is

DNA replication?

DNA replication is the process of making two identical copies from one original DNA molecule.

Step 2

One of the most important steps of DNA Replication is the binding of RNA Primase in the the starting point of the 3'-5' parent chain.

RNA Primase can attract RNA nucleotides which bind to the DNA nucleotides of the 3'-5' strand due to the hydrogen bonds between the bases.

DNA Replication

Step 1

The first is the breaking of hydrogen bonds. The unwounding of the two strands is the starting point.

The splitting happens in places of the chains which are rich in A-T.

Helicase is the enzyme that splits the two strands.

The initiation point where the splitting starts is called "origin of replication".

Step 3

BY EMILY WISE AND ARIANNA MOJICA

The elongation process is different for the 5'-3' and 3'-5' template.

5'-3' Template: The 3'-5' proceeding daughter strand -that uses a 5'-3' template- is called leading strand.

3'-5'Template: The 3'-5' template cannot be "read" by DNA Polymerase ä.

The replication of this template is complicated and the new strand is called lagging strand.

DNA polymerase å reads the template and lengthens the bursts.

The gap between two RNA primers is called "Okazaki Fragments".

Step 4

In the lagging strand the DNA reads the fragments and removes the RNA Primers.

The gaps are closed with the action of DNA Polymerase and DNA Ligase.

Step 6

The DNA Replication is not done before a mechanism of repair fixes possible mistakes caused during the replication. Enzymes like nucleases take out the wrong nucleotides and the DNA Polymerase fills the gaps.

Step 5

So, the end of the parental strand where the last primer binds isn't replicated. These ends of linear (chromosomal) DNA consists of noncoding DNA that contains repeat sequences and are called telomeres. As a result, a part of the telomere is taken out in every cycle of DNA Replication.

The last step of DNA Replication is the Termination. This process happens when the DNA Polymerase reaches to an end of the strands. In the last section of the lagging strand, when the RNA primer is removed, it is not possible for the DNA Polymerase to close the gap.

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