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Coffee and Pancreatic Cancer
Transcript
"A strong association between coffee consumption and pancreatic cancer was evident in both sexes."
Coffee
and Cancer of the Pancreas
Brian MacMahon, M.D., Stella Yen, M.D., Dimitrios Trichopoulos, M.D., Kenneth Warren, M.D., and George Nardi, M.D.
Methods
Case-Control Interview Study
- 369 Cases
- Patients with histologically proved cancer of the pancreas from 11 hospitals in Boston and Rhode Island
- 644 Controls
- Controls were matched to cases by the same physician in the same hospital
- Those with diseases associated with smoking, alcohol, or the pancreas were excluded
- 273 had cancer and 371 had other diseases
Statistical Analysis
- Calculated relative risk of pancreatic cancer based on selected variables
- Separated the controls into those with cancer and those without, but results were similar so the controls were all grouped together
- Stratified by:
- Age in 10 year groups
- Sex
Results:
- There was no significant association shown for pipe tobacco, cigars or alcohol assumption.
- Smoking showed a RR of 1.4 (1.1,1.9)
- Coffee was significant with RR of 2.1 for consumers of 1-2 cups, 2.8 for 3-4 cups & 3.2 for 5 or more cups per day.
Things to consider:
- The study was not initially designed to look at coffee consumption.
- Controls with diseases associated with smoking and alcohol were excluded
Pancreatic Cancer
Coffee Consumption
By: Lucy D'Agostino and Renee Gennarelli
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