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Spontaneous Calcium Oscillations in Astrocytes

Caroline Adlam, Andrew Bullock, Jack Elsdon,

Sabrina Lester, Delina Pereira, Sarah Roberts

Results

2 - Maximal flux across SERCA

Results

Summary

3 - Maximal flux across IP3 receptor

Results

Our Focus

SERCA pump

IP3 Receptor

1 - Omitting VGCCs

  • We changed IP3R and SERCA properties
  • Changes in frequency
  • Link to diseases, such as epilepsy and cancer

Results

4 - Calcium activating affinity

Background

  • Calcium-induced calcium release
  • Inositol cross-coupling

Results

5 - Calcium inhibiting affinity

Limitations

  • Unicellular
  • Empirical parameters
  • Buffer proteins
  • VGCCs
  • Physiological systems

Methods

  • mSERCA: Maximum flux across the SERCA pump
  • mIP3R: Maximum flux through IP3 receptor
  • pCaI: Inhibiting affinities
  • pCaA: Activating affinities

Future Work

  • Omit VGCCs
  • Signal-induced calcium oscillations
  • In vitro experiments
  • Channel antagonists as drug targets

Thank you

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