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Drug Delivery Now

What Drugs Are Headed Towards Microchips?

References

How the Microchip Works

Problems

Why Are Microchips Better?

What is the future of drug delivery?

What's Going On Now?

  • Pills
  • Either in tablet or capsule form (some caplets dissolve easier; delivery systems differ)
  • Injections
  • Go immediately into bloodstream, painful to take
  • Pumps
  • e.g. diabetes pumps
  • Transdermally
  • can administer slowly, start towards right direction
  • Multiple Sclerosis
  • Chemotherapy and cancer drugs
  • Dental treatments (pain medicines and periodontal disease)
  • Type 2 Diabetes
  • Type 1 Diabetes
  • Controlling anaphylaxis response
  • Asthma
  • Many More!!!
  • Some sensors in microchip don't pick up on reservoir failure enough
  • Possible hacking with dangerous results
  • Unique serial numbers per device
  • possible development of encryption
  • Scar left by implant surgery
  • will eventually be reduced to nothing
  • Implanted under subcutaneous tissue (lowest layer of skin)
  • Use of complicated reservoir system
  • titanium fused, electric current melts metal to administer drugs
  • involves radio frequencies, real-time
  • different dosing schedules
  • Can be remote controlled!!!
  • Use of biofeedback to further aid customization
  • Maybe include in mobile app?
  • Chance to consult doctor through applications
  • Use of multiple drugs at a time
  • Ability to use biodegradable ingredients
  • Higher accuracy

http://www.controlledreleasesociety.org/publications/intrack/Pages/it0011.aspx

http://microchipsbiotech.com/news-pub.php

http://www.technologyreview.com/news/528121/a-contraceptive-implant-with-remote-control/

http://www.fiercedrugdelivery.com/story/mit-microchips-develop-remote-controlled-contraceptive-delivery/2014-07-08

  • Robert S. Langer, MIT, started research on new drug delivery mechanisms
  • Bill Gates wanted research done, too!
  • Goals with long-term delivery systems
  • Needed to figure out effective way
  • Since they are controlled mechanisms, make easier to do testing
  • When smart, can be externally activated
  • MicroCHIPS trying to utilize mobile apps
  • Customized dosing strategies makes more personal to patient
  • on-demand, programmed schedule, or in response to stimuli
  • Once widely implemented, will reduce costs to patient

Technology with Microchip Delivery

What's wrong with today's medicine?

Drugs In Testing Now

  • Plasma drug levels that go too high or too low
  • Non-consistent methods for delivery (people misusing or forgetting drugs)
  • Very hard to customize amounts of drugs administered
  • Decided on microchip delivery after conversations with Bill Gates, already partnered up with many investors
  • Needed effective mechanism to reliably release same amount of drug over long periods of time
  • Osteoporosis
  • were first to have trial runs with patients
  • very successful
  • Contraception
  • also very successful, would totally replace current methods
  • has enough drug reservoirs to last 16 years!!!

Microchip Drug Delivery

Presentation By: Alana Frenkel

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