Drug Delivery Now
What Drugs Are Headed Towards Microchips?
References
How the Microchip Works
Problems
Why Are Microchips Better?
What is the future of drug delivery?
What's Going On Now?
- Pills
- Either in tablet or capsule form (some caplets dissolve easier; delivery systems differ)
- Injections
- Go immediately into bloodstream, painful to take
- Pumps
- e.g. diabetes pumps
- Transdermally
- can administer slowly, start towards right direction
- Multiple Sclerosis
- Chemotherapy and cancer drugs
- Dental treatments (pain medicines and periodontal disease)
- Type 2 Diabetes
- Type 1 Diabetes
- Controlling anaphylaxis response
- Asthma
- Many More!!!
- Some sensors in microchip don't pick up on reservoir failure enough
- Possible hacking with dangerous results
- Unique serial numbers per device
- possible development of encryption
- Scar left by implant surgery
- will eventually be reduced to nothing
- Implanted under subcutaneous tissue (lowest layer of skin)
- Use of complicated reservoir system
- titanium fused, electric current melts metal to administer drugs
- involves radio frequencies, real-time
- different dosing schedules
- Can be remote controlled!!!
- Use of biofeedback to further aid customization
- Maybe include in mobile app?
- Chance to consult doctor through applications
- Use of multiple drugs at a time
- Ability to use biodegradable ingredients
- Higher accuracy
http://www.controlledreleasesociety.org/publications/intrack/Pages/it0011.aspx
http://microchipsbiotech.com/news-pub.php
http://www.technologyreview.com/news/528121/a-contraceptive-implant-with-remote-control/
http://www.fiercedrugdelivery.com/story/mit-microchips-develop-remote-controlled-contraceptive-delivery/2014-07-08
- Robert S. Langer, MIT, started research on new drug delivery mechanisms
- Bill Gates wanted research done, too!
- Goals with long-term delivery systems
- Needed to figure out effective way
- Since they are controlled mechanisms, make easier to do testing
- When smart, can be externally activated
- MicroCHIPS trying to utilize mobile apps
- Customized dosing strategies makes more personal to patient
- on-demand, programmed schedule, or in response to stimuli
- Once widely implemented, will reduce costs to patient
Technology with Microchip Delivery
What's wrong with today's medicine?
Drugs In Testing Now
- Plasma drug levels that go too high or too low
- Non-consistent methods for delivery (people misusing or forgetting drugs)
- Very hard to customize amounts of drugs administered
- Decided on microchip delivery after conversations with Bill Gates, already partnered up with many investors
- Needed effective mechanism to reliably release same amount of drug over long periods of time
- Osteoporosis
- were first to have trial runs with patients
- very successful
- Contraception
- also very successful, would totally replace current methods
- has enough drug reservoirs to last 16 years!!!
Microchip Drug Delivery
Presentation By: Alana Frenkel