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Eosinophils attach themselves to the parasite :
Cellular ingestion of the offending agent. Phagocytes MUST be SELECTIVE of what material will be phagocytized
Natural tissues structure that resist phagocytosis
1- Attaches to the particle
2- Projects pseudopodia in all directions around the particle
3-The pseudopodia meet one another on the opposite side and fuse < this creates a closed chamber around that contain the particle
4- Chamber invaginates to the inside of the CP cavity to form a free-floading phagocytic vesicle
A single neutrophil can phagocytize 3 to 20 bacteria
The immune system develops antibodies against infectious agents. The antibody adhere to bacterial membrane and make it susceptible to phagocytosis.
1- Similar to the tissue mast cells outside many of the capillaries.
2- Both liberate heparin into the blood; prevent blood cloagulation.
3- They release histamine, bradykinin & serotonin.
1- The immunoglobin IgE attaches to basophils and mast cells.
2- The specific antigen will bind to the IgE.
3- It causes the basophil or mast cell to rapture and release ; histamine, bradykinin, serotonin & lysosomal enzymes.
5- Local vascular and tissue reactions that causes allergic manifestations
After being released from the bone marrow 4-8 hrs in blood
In tissues 4-5 days where they are needed
In a serious infection, the life span is shortened to only few hours
Polymorphonuclear neutrophils 62.0%
Polymorphonuclear eosinophils 2.3%
Polymorphonuclear basophils 0.4%
Monocytes 5.3%
Lymphocytes 30.0%
In blood 10-20 hours
In tissues they swell to become macrophages and they can live for months
Blood
From lymph nodes/tissues