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Brain-derived Neurotrophic Factor

BDNF Protein Comparison

BDNF Protein

% Identity Matrix

Function

1: 2: 3:

Structure

  • aid in survival of existing neurons
  • neurogenesis
  • neurons
  • growth
  • synapses
  • differentiation
  • dimeric protein
  • Binds to TrkB and other growth factors

Family

part of neurotrophin family of growth factors

Bioinformatics

BDNF Gene Comparison

BDNF Gene

% Identity Matrix

Logistics of BDNF

Organisms

Psychological Disorders

  • chronic stress (Murakami)
  • depression (Li)
  • anxiety (Zielenski)

Neurodegenerative Diseases

  • Alzheimer's Disease (Intlekofer)
  • Huntington's Disease (Hedlin)

Genetic Syndromes

  • WAGR Syndrome (Han)

Locations and Importance

Non-Functionality of BDNF Protein

Causes

  • Brain
  • Hippocampus
  • short-term to long-term memory
  • Cerebral Cortex
  • learning
  • higher order thinking
  • movement
  • Basal Forebrain
  • learning
  • Muscles
  • repair
  • regeneration
  • differentiation
  • old age
  • mutations
  • drug addictions

Scholarly Review Article

Abstract:

"Alzheimer's disease (AD) afflicts more than 5.4 million Americans and ranks as the most common type of dementia (Thies and Bleiler, 2011), yet effective pharmacological treatments have not been identified. Substantial evidence indicates that physical activity enhances learning and memory for people of all ages, including individuals that suffer from cognitive impairment. The mechanisms that underlie these benefits have been explored using animal models, including transgenic models of AD. Accumulating research shows that physical activity reinstates hippocampal function by enhancing the expression of brain-derived neuro- trophic factor (BDNF) and other growth factors that promote neurogenesis, angiogenesis, and synaptic plasticity. In addition, several studies have found that physical activity counteracts age- and AD-associated declines in mitochondrial and immune system function. A growing body of evidence also suggests that exercise interven- tions hold the potential to reduce the pathological features associated with AD. Taken together, animal and human studies indicate that exercise provides a powerful stimulus that can countervail the molecular changes that underlie the progressive loss of hippocampal function in advanced age and AD." (Intlekofer)

Bibliography

Treatments/Preventions

  • exercise
  • proper diet
  • artificial/produced BDNF (Allen)
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